Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males

doi:10.3748/wjg.14.1444

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	Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males
	Guo, YM; Wang, Q; Liu, YZ; Chen, HM; Qi, Z; Guo, QH; Guo, YM (reprint author), Gansu Coll Tradit Chinese Med, Dept Clin Med, Lanzhou 730000, Gansu, Peoples R China.
刊名	WORLD JOURNAL OF GASTROENTEROLOGY
	2008-03-07
卷号	14 期号:9 页码:1444-1449
关键词	esophageal squamous cell carcinoma cytochromes P4502E1 alcohol dehydrogenases aldehyde dehydrogenases genetic polymorphisms
ISSN号	1007-9327
DOI	10.3748/wjg.14.1444
文献子类	Article
英文摘要	AIM: To evaluate the association between genetic polymorphisms in CYP2E1, ALDH2 and ADH1B and the risk of esophageal squamous cell carcinoma (ESCC) in a high risk area of Gansu province, in Chinese males. METHODS: A case-control study was conducted to investigate the genetic polymorphisms of these enzymes (CYP2E1c1/c2, ALDH21/2 and ADH1B 1/1 genotypes). A total of 80 esophageal cancer cases and 480 controls were recruited. RESULTS: Compared with controls, cases had a greater prevalence of heavier alcohol consumption (53.8% vs 16.2%) and a higher proportion of alcohol drinkers with > 30 drink-years (28.8% vs 13.5%). Heavier alcohol consumption and alcohol drinking with > 30 drink-years increased the risk of ESCC, with ORs (95% CI) of 3.20 (1.32-9.65) and 1.68 (0.96-3.21). CYP2E1 (c1/c1), ALDH2 (1/2) and ADH1B (1/1) genotype frequencies were higher among patients with squamous cell carcinomas, at a level close to statistical significance (P = 0.014; P = 0.094; P = 0.0001 respectively). There were synergistic interactions among alcohol drinking and ALDH2, ADH1B and CYP2E1 genotypes. The risk of the ESCC in moderate-to-heavy drinkers with an inactive ALDH2 encoded by ALDH21/2 as well as ADH1B encoded by ADH1B 1/1 and CYP2EI encoded by CYP2EI c1/c1 was higher than that in the never/rare-to-light drinkers with an active ALDH2 (1/1 genotype) as well as ADH1B (1/2 + 2/2) and CYP2E1 (c1/c2 + c2/c2) genotypes, with a statistically significant difference; ORs (95% CI) of 8.58 (3.28-22.68), 27.12 (8.52-70.19) and 7.64 (2.82-11.31) respectively. The risk of the ESCC in moderate-to-heavy drinkers with ALDH2 (1/2) combined the ADH1B (1/1) genotype or ALDH2 (1/2) combined the CYP2E1 (c1/c1) genotype leads to synergistic interactions, higher than drinkers with ALDH2 (1/1) + ADH1B (1/2 + 2/2), ALDH2 (1/1) + CYP2E1 (c1/c2 + c2/c2) respectively, ORs (95% CI) of 7.46 (3.28-18.32) and 6.82 (1.44-9.76) respectively. Individuals with the ADH1B combined the CYP2E1 genotype showed no synergistic interaction. CONCLUSION: In our study, we found that alcohol consumption and polymorphisms in the CYP2E1, ADH1B and ALDH2 genes are important risk factors for ESCC, and that there was a synergistic interaction among polymorphisms in the CYP2E1, ALDH2 and ADH1B genes and heavy alcohol drinking, in Chinese males living in Gansu province, China. (c) 2008 WJG. All rights reserved.
学科主题	Gastroenterology & Hepatology
出版地	BEIJING
语种	英语
WOS记录号	WOS:000253866400024
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125663]
专题	第一临床医学院_期刊论文
通讯作者	Guo, YM (reprint author), Gansu Coll Tradit Chinese Med, Dept Clin Med, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Guo, YM,Wang, Q,Liu, YZ,et al. Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(9):1444-1449.
APA	Guo, YM.,Wang, Q.,Liu, YZ.,Chen, HM.,Qi, Z.,...&Guo, YM .(2008).Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males.WORLD JOURNAL OF GASTROENTEROLOGY,14(9),1444-1449.
MLA	Guo, YM,et al."Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males".WORLD JOURNAL OF GASTROENTEROLOGY 14.9(2008):1444-1449.