Effect of celecoxib on E-cadherin, VEGF, microvessel density and apoptosis in gastric cancer

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	Effect of celecoxib on E-cadherin, VEGF, microvessel density and apoptosis in gastric cancer
	Zhou, YN; Ran, JT; Tang, CW; Wu, J; Li, HH; Li, XW; Ning, C; Qiao, L; Qiao, L (reprint author), Univ Hong Kong, Queen Mary Hosp,Fac Med, Dept Med, Div Gastroenterol & Hepatol, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China.
刊名	CANCER BIOLOGY & THERAPY
	2007-02
卷号	6 期号:2 页码:269-275
关键词	COX-2 inhibitor gastric cancer chemoprevention apoptosis angiogenesis
ISSN号	1538-4047
文献子类	Article
英文摘要	Cyclooxygenase-2 (COX-2) plays a crucial role in the development and invasion of gastric cancer. COX-2 inhibitors have been shown to be chemopreventive against gastrointestinal cancers. In vitro studies have suggested that the mechanisms may be related to induction of apoptosis and inhibition of angiogenesis. COX-2 may also have impact on E-cadherin. In our study we investigate the effect of Celecoxib on expression of E-cadherin and serum soluble E-cadherin, as well as on apoptosis and angiogenesis in patients with gastric cancer. Fifty nine gastric cancer patients were randomly divided into two groups: Surgery group (n = 22), in which patients underwent surgical resection after diagnosis, and Celecoxib + Surgery group ( n = 37), in which patients received oral Celecoxib 200 mg twice daily for 7 days before curative resection. Twenty healthy subjects ( Healthy controls) were recruited as normal controls. After curative resection, COX-2, E-cadherin, VEGF, and MVD were detected by immunohistochemistry. Serum soluble E-cadherin was quantitatively measured using a commercially available enzyme-linked immunosorbent assay kit. Apoptosis was determined by TUNEL assay. Significantly decreased expression of COX-2, increased E-cadherin and apoptosis, decreased VEGF and MVD were observed in gastric cancer tissues from patients receiving Celecoxib compared to Surgery group. Compared to Healthy controls, the serum soluble E-cadherin levels were higher in gastric cancer patients which were decreased by Celecoxib. This in vivo study demonstrated that Celecoxib induces apoptosis and inhibit angiogenesis of gastric cancer. Its impact on E-cadherin may suggest that this agent may suppress the invasion of advanced gastric cancer.
学科主题	Oncology
出版地	GEORGETOWN
语种	英语
WOS记录号	WOS:000245851800034
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125660]
专题	第一临床医学院_期刊论文
通讯作者	Qiao, L (reprint author), Univ Hong Kong, Queen Mary Hosp,Fac Med, Dept Med, Div Gastroenterol & Hepatol, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China.
推荐引用方式 GB/T 7714	Zhou, YN,Ran, JT,Tang, CW,et al. Effect of celecoxib on E-cadherin, VEGF, microvessel density and apoptosis in gastric cancer[J]. CANCER BIOLOGY & THERAPY,2007,6(2):269-275.
APA	Zhou, YN.,Ran, JT.,Tang, CW.,Wu, J.,Li, HH.,...&Qiao, L .(2007).Effect of celecoxib on E-cadherin, VEGF, microvessel density and apoptosis in gastric cancer.CANCER BIOLOGY & THERAPY,6(2),269-275.
MLA	Zhou, YN,et al."Effect of celecoxib on E-cadherin, VEGF, microvessel density and apoptosis in gastric cancer".CANCER BIOLOGY & THERAPY 6.2(2007):269-275.