Metal-Organic Frameworks/Graphene Oxide Composite: A New Enzymatic Immobilization Carrier for Hydrogen Peroxide Biosensors

doi:10.1149/2.0531603jes

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	Metal-Organic Frameworks/Graphene Oxide Composite: A New Enzymatic Immobilization Carrier for Hydrogen Peroxide Biosensors
	Fan, ZJ; Wang, JQ; Nie, YY; Ren, LL; Liu, B; Liu, G; Liu, B (reprint author), Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China.
刊名	JOURNAL OF THE ELECTROCHEMICAL SOCIETY
	2016
卷号	163 期号:3 页码:B32-B37
ISSN号	0013-4651
DOI	10.1149/2.0531603jes
文献子类	Article
英文摘要	Enzymatic loss and inactivation are two main problems that can degrade the performance of biosensor. In order to resolve the problems, a new enzymatic immobilization carrier was developed by using biomimetic methods. Horseradish peroxidase (HRP) was initially encapsulated into zeolitic imidazolate frameworks (ZIFs) severed as protective structure. To overcome electron transfer barrier of ZIFs, graphene oxide (GO) of high conductive graphene precursor was used to enhance their conductivity. Subsequently, ZIFs@HRP/GO and GO-polyethyleneimine with opposite charges were alternatively assembled onto the substrate of indium tin oxide to construct multilayer films of the biosensor. Systematic characterizations showed that ZIF-8 with an average size of approximately 160.9 nm encapsulating HRP uniformly grew onto the surface of GO. The newly designed structure combined with the excellent properties of the GO and ZIFs guarantee easy, direct electrochemistry and good catalytic activity toward H2O2 oxidation can be achieved with this biosensor. Electrochemical experiment study indicate that the resulting biosensor presented a wide linear range of 0.02-6 mmol/L, a low detection limit of 3.4 mu mol/L (S/N = 3), excellent anti-interference ability, and long-term stability as well. (C) 2015 The Electrochemical Society. All rights reserved.
学科主题	Electrochemistry ; Materials Science
出版地	PENNINGTON
资助项目	国家自然科学基金项目 ; 中央高校基本科研业务费专项资金 ; 甘肃省青年科技基金计划
项目编号	Natural Science Foundation of China [81571829] ; Fundamental Research Funds for the Central Universities [lzujbky-2015-35, lzujbky-2015-289, lzujbky-2015-102] ; Natural Science Foundation of Gansu Province, China [145RJZA126] ; Science and Technology Projects of Gansu Province, China [145RJYA315] ; Youth Science and Technology Innovation Foundation of Gansu Academy of Sciences, China [2013 QN-02]
语种	英语
WOS记录号	WOS:000370861500043
资助机构	NSFC ; LZU ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179470]
专题	口腔医学院_期刊论文
通讯作者	Fan, ZJ; Liu, B (reprint author), Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Fan, ZJ,Wang, JQ,Nie, YY,et al. Metal-Organic Frameworks/Graphene Oxide Composite: A New Enzymatic Immobilization Carrier for Hydrogen Peroxide Biosensors[J]. JOURNAL OF THE ELECTROCHEMICAL SOCIETY,2016,163(3):B32-B37.
APA	Fan, ZJ.,Wang, JQ.,Nie, YY.,Ren, LL.,Liu, B.,...&Liu, B .(2016).Metal-Organic Frameworks/Graphene Oxide Composite: A New Enzymatic Immobilization Carrier for Hydrogen Peroxide Biosensors.JOURNAL OF THE ELECTROCHEMICAL SOCIETY,163(3),B32-B37.
MLA	Fan, ZJ,et al."Metal-Organic Frameworks/Graphene Oxide Composite: A New Enzymatic Immobilization Carrier for Hydrogen Peroxide Biosensors".JOURNAL OF THE ELECTROCHEMICAL SOCIETY 163.3(2016):B32-B37.