Syntheses, properties and bio-activities of water-soluble CO-releasing molecule based on manganese.

doi:10.1007/s00775-016-1379-2

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	Syntheses, properties and bio-activities of water-soluble CO-releasing molecule based on manganese.
	Zhang, Taofeng; Li, Meng; Gong, Yaguo; Xi, Na; Zheng, Yawen; Zhao, Quanyi; Chen, Yonglin; Liu, Bin; Zhao, QY (reprint author), Lanzhou Univ, Inst Med Chem, Sch Pharm, Lanzhou 730000, Peoples R China.
刊名	Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
	2016-10
卷号	21 期号:7 页码:807-824
关键词	CO-releasing molecule Manganese Toxicity Anti-inflammatory
ISSN号	1432-1327
DOI	10.1007/s00775-016-1379-2
文献子类	Article
英文摘要	A series of water-soluble CO-releasing molecules, [Mn(CO)(3)NH2CHRCO2](2) (1-3), [M(CO)(3)Br[(Py-C = N)(Gly) (n) CO2] (M = Mn, Re, 4-7), Mn(CO)(4)[S2CNC (m) H (n) CO2] (8-12), were synthesized and characterized by H-1 NMR, IR and ESI-HRMS. The stability of all the complexes in solution was evaluated by means of UV, IR and H-1 NMR. Among all the complexes, complex 4 and complex 8 were stable in H2O, acidic aqueous solution and basic media; complex 1 was stable in acidic aqueous solution and weak basic media (pH < 9.4). The assays showed that each complex has CO-release ability; excess sodium dithionite can enhance CO release. Among them, complexes 8-12 were fast CO-releasers. In the test of the cell proliferation, all the complexes showed anti-proliferative activities for HeLa and HepG2. In particular, complex 8 displayed a 3.5-fold anti-proliferative activity on HeLa cells (IC50 23.13 mu M) and fivefold on HepG2 cells (34.00 mu M) compared with 5-FU. What is more, the complexes distinctly influenced cell cycle and promoted cell apoptosis; complex 1 arrested HeLa cells in S phase, whereas complex 4 and complex 8 arrested in G2/M phase; all the complexes induced HeLa cells "Early apoptosis". In addition, all complexes 1, 4 and 8 decreased intracellular nitrite levels, and complex 8 was stronger than both of the others. All these data demonstrate that complex 8 has potential to be a drug candidate. Three different categories of water-soluble CORMs 1-12 were synthesized, and their stability were evaluated. The biological activities were preliminarily evaluated. This includes anti-proliferation and anti-inflammatory properties. .
学科主题	Biochemistry & Molecular Biology ; Chemistry
出版地	NEW YORK
语种	英语
WOS记录号	WOS:000385147900001
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179598]
专题	药学院_期刊论文
通讯作者	Zhao, QY (reprint author), Lanzhou Univ, Inst Med Chem, Sch Pharm, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, Taofeng,Li, Meng,Gong, Yaguo,et al. Syntheses, properties and bio-activities of water-soluble CO-releasing molecule based on manganese.[J]. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry,2016,21(7):807-824.
APA	Zhang, Taofeng.,Li, Meng.,Gong, Yaguo.,Xi, Na.,Zheng, Yawen.,...&Zhao, QY .(2016).Syntheses, properties and bio-activities of water-soluble CO-releasing molecule based on manganese..Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry,21(7),807-824.
MLA	Zhang, Taofeng,et al."Syntheses, properties and bio-activities of water-soluble CO-releasing molecule based on manganese.".Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 21.7(2016):807-824.