Metabolome Analysis of Oryza sativa (Rice) Using Liquid Chromatography-Mass Spectrometry for Characterizing Organ Specificity of Flavonoids with Anti-inflammatory and Anti-oxidant Activity

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	Metabolome Analysis of Oryza sativa (Rice) Using Liquid Chromatography-Mass Spectrometry for Characterizing Organ Specificity of Flavonoids with Anti-inflammatory and Anti-oxidant Activity
	Yang, ZG; Nakabayashi, R; Mori, T; Takamatsu, S; Kitanaka, S; Saito, K; Saito, K (reprint author), RIKEN, Ctr Sustainable Resource Sci, Tsurumi Ku, 1-7-22 Suehiro, Yokohama, Kanagawa 2300045, Japan.; Saito, K (reprint author), Chiba Univ, Grad Sch Pharmaceut Sci, 1-8-1 Inohana, Chiba 2608675, Japan.
刊名	CHEMICAL & PHARMACEUTICAL BULLETIN
	2016-07
卷号	64 期号:7 页码:952-956
关键词	Oryza sativa rice specialized metabolite anti-inflammatory anti-oxidant
ISSN号	0009-2363
文献子类	Article
英文摘要	Oryza sativa L. (rice) is an important staple crop across the world. In the previous study, we identified 36 specialized (secondary) metabolites including 28 flavonoids. In the present study, a metabolome analysis using liquid chromatography-mass spectrometry was conducted on the leaf, bran, and brown and polished rice grains to better understand the distribution of these metabolites. Principal component analysis using the metabolome data clearly characterized the accumulation patterns of the metabolites. Flavonoids, e.g., tricin, tricin 7-O-rutinoside, and tricin 7-O-beta-D-glucopyranoside, were mainly present in the leaf and bran but not in the polished grain. In addition, anti-inflammatory and anti-oxidant activity of the metabolites were assayed in vitro. Tricin 4'-O-(erythro-beta-guaiacylglyceryl)ether and isoscoparin 2 ''-O-(6 ''-(E)-feruloyl)glucopyranoside showed the strongest activity for inhibiting nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging, respectively.
学科主题	Pharmacology & Pharmacy ; Chemistry
出版地	TOKYO
项目编号	Japan Science and Technology Agency (JST) ; Strategic International Collaborative Research Program (SICORP) ; Japan Advanced Plant Science Research Network
语种	英语
WOS记录号	WOS:000378974500041
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179593]
专题	药学院_期刊论文
通讯作者	Saito, K (reprint author), RIKEN, Ctr Sustainable Resource Sci, Tsurumi Ku, 1-7-22 Suehiro, Yokohama, Kanagawa 2300045, Japan.; Saito, K (reprint author), Chiba Univ, Grad Sch Pharmaceut Sci, 1-8-1 Inohana, Chiba 2608675, Japan.
推荐引用方式 GB/T 7714	Yang, ZG,Nakabayashi, R,Mori, T,et al. Metabolome Analysis of Oryza sativa (Rice) Using Liquid Chromatography-Mass Spectrometry for Characterizing Organ Specificity of Flavonoids with Anti-inflammatory and Anti-oxidant Activity[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2016,64(7):952-956.
APA	Yang, ZG.,Nakabayashi, R.,Mori, T.,Takamatsu, S.,Kitanaka, S.,...&Saito, K .(2016).Metabolome Analysis of Oryza sativa (Rice) Using Liquid Chromatography-Mass Spectrometry for Characterizing Organ Specificity of Flavonoids with Anti-inflammatory and Anti-oxidant Activity.CHEMICAL & PHARMACEUTICAL BULLETIN,64(7),952-956.
MLA	Yang, ZG,et al."Metabolome Analysis of Oryza sativa (Rice) Using Liquid Chromatography-Mass Spectrometry for Characterizing Organ Specificity of Flavonoids with Anti-inflammatory and Anti-oxidant Activity".CHEMICAL & PHARMACEUTICAL BULLETIN 64.7(2016):952-956.