Anti-hypoxia Activity of the Novel NO Donor Acetyl Ferulic Isosorbide Mononitrate in Acute High-Altitude Hypoxia Mice

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	Anti-hypoxia Activity of the Novel NO Donor Acetyl Ferulic Isosorbide Mononitrate in Acute High-Altitude Hypoxia Mice
	Fan, PC; Ma, HP; Jiang, W; Li, L; Ren, J; Jing, LL; Jia, ZP; Jing, LL (reprint author), Gen Hosp Lanzhou Command PLA, Dept Pharm, Lanzhou 730050, Peoples R China.
刊名	BIOLOGICAL & PHARMACEUTICAL BULLETIN
	2015-09
卷号	38 期号:9 页码:1280-1289
关键词	altitude hypoxia nitric oxide acetyl ferulic isosorbide mononitrate
ISSN号	0918-6158
文献子类	Article
英文摘要	Nitric oxide (NO) may act as either a pro-oxidant or an antioxidant in biological systems. Previous work has found inhalation of NO improved survival in a high altitude rat model. NO donor isosorbide mononitrate derivants might have a protective effect against hypoxia. We synthesized a series of isosorbide mononitrate derivant compounds to test their anti-hypoxia activities. Normobaric hypoxia and hypobaric hypoxia models were used to study the protective role of NO donor in mice. The results showed isosorbide mononitrate derivants had protective effects in hypoxia mice. Among those compounds, acetyl ferulic isosorbide mononitrate (AFIM) was the most effective. It prolonged the survival time during the normobaric hypoxia test. It decreased malondialdehyde (MDA) and H2O2 in hypobaric hypoxia mice. The antioxidase activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) remained in normal ranges in the AFIM group. As a sign of mitochondrial dysfunction, the activities of ATPase were down regulated in mice under hypobaric hypoxia conditions. AFIM also protected ATPase activities. The protective effects of AFIM might come from a sustained NO supply and the release of acetyl ferulic acid with anti-oxidant activity.
学科主题	Pharmacology & Pharmacy
出版地	TOKYO
资助项目	国家自然科学基金项目 ; 甘肃省杰出青年基金计划
项目编号	Chinese National Natural Science Foundation [81402848] ; Gansu Natural Science Foundation [145RJDA331]
语种	英语
WOS记录号	WOS:000360599300004
资助机构	NSFC ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179558]
专题	药学院_期刊论文
通讯作者	Jing, LL (reprint author), Gen Hosp Lanzhou Command PLA, Dept Pharm, Lanzhou 730050, Peoples R China.
推荐引用方式 GB/T 7714	Fan, PC,Ma, HP,Jiang, W,et al. Anti-hypoxia Activity of the Novel NO Donor Acetyl Ferulic Isosorbide Mononitrate in Acute High-Altitude Hypoxia Mice[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2015,38(9):1280-1289.
APA	Fan, PC.,Ma, HP.,Jiang, W.,Li, L.,Ren, J.,...&Jing, LL .(2015).Anti-hypoxia Activity of the Novel NO Donor Acetyl Ferulic Isosorbide Mononitrate in Acute High-Altitude Hypoxia Mice.BIOLOGICAL & PHARMACEUTICAL BULLETIN,38(9),1280-1289.
MLA	Fan, PC,et al."Anti-hypoxia Activity of the Novel NO Donor Acetyl Ferulic Isosorbide Mononitrate in Acute High-Altitude Hypoxia Mice".BIOLOGICAL & PHARMACEUTICAL BULLETIN 38.9(2015):1280-1289.