Metal-Free Difunctionalization of Alkynes with 2-Chlorodithiane for Synthesis of beta-Ketodithianes

doi:10.1021/acs.joc.5b00187

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	Metal-Free Difunctionalization of Alkynes with 2-Chlorodithiane for Synthesis of beta-Ketodithianes
	Lai, JS; Tian, LX; Huo, X; Zhang, Y; Xie, XG; Tang, SC; Tang, SC (reprint author), Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China.
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2015-06-05
卷号	80 期号:11 页码:5894-5899
ISSN号	0022-3263
DOI	10.1021/acs.joc.5b00187
其他题名	Metal-free difunctionalization of alkynes with 2-chlorodithiane for synthesis of β-ketodithianes
文献子类	Article
英文摘要	Dithianes are versatile umpolung intermediates in organic synthesis but have rarely been employed in radical cross-coupling reactions. Here we describe the oxidative coupling method for alkyne difunctionalization under metal-catalyst-free conditions. The efficient protocol directly affords a variety of beta-ketodithianes in good to excellent yields with high regioselectivities. It provides a general pathway for accessing valuable dithianes with controlled formation of a new C-C bond and a C-O bond via a radical coupling pathway.
学科主题	Chemistry
出版地	WASHINGTON
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [21102064, 21102066, lanzhoukeji2013-4-116]
语种	英语
WOS记录号	WOS:000355962300055
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179550]
专题	药学院_期刊论文
通讯作者	Tang, SC (reprint author), Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Lai, JS,Tian, LX,Huo, X,et al. Metal-Free Difunctionalization of Alkynes with 2-Chlorodithiane for Synthesis of beta-Ketodithianes[J]. JOURNAL OF ORGANIC CHEMISTRY,2015,80(11):5894-5899.
APA	Lai, JS.,Tian, LX.,Huo, X.,Zhang, Y.,Xie, XG.,...&Tang, SC .(2015).Metal-Free Difunctionalization of Alkynes with 2-Chlorodithiane for Synthesis of beta-Ketodithianes.JOURNAL OF ORGANIC CHEMISTRY,80(11),5894-5899.
MLA	Lai, JS,et al."Metal-Free Difunctionalization of Alkynes with 2-Chlorodithiane for Synthesis of beta-Ketodithianes".JOURNAL OF ORGANIC CHEMISTRY 80.11(2015):5894-5899.