THE PREVENTIVE EFFECT AND ENHANCE IMMUNITY FUNCTION OF BU-ZHONG-YI-QIWAN ON S180 TUMOR MICE

doi:10.4314/ajtcam.v13i3.8

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	THE PREVENTIVE EFFECT AND ENHANCE IMMUNITY FUNCTION OF BU-ZHONG-YI-QIWAN ON S180 TUMOR MICE
	Hu, F; Liu, XY; Chen, XY; Li, C; Zhu, RJ; Han, H; Li, YD; Feng, SL; Feng, SL (reprint author), Lanzhou Univ, Sch Pharm, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.
刊名	AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES
	2016
卷号	13 期号:3 页码:60-65
关键词	Bu-zhong-yi-qi wan S180 tumor-bearing mice preventive immunity
ISSN号	0189-6016
DOI	10.4314/ajtcam.v13i3.8
文献子类	Article
英文摘要	Background: To evaluate the preventive effect and enhance immunity functions of Bu-zhong-yi-qi wan in vivo. Materials and Methods: S180 tumor mice model was established by subcutaneous injection a dose of 0.2 ml (1x10(7)/ml) at the right oxter. The inhibitory rates, spleen indexes and thymus indexes were calculated. Splenic lymphocyte proliferative activity assay and phagocytosis activity of peritoneal macrophages were done. Interferon (IFN-gamma), interleukin (IL-2) and tumor necrotic factor (TNF-alpha) in serum were detected. Results: In the S180 tumor-bearing mice, Bu-zhong-yi-qi wan with medium-dose (975 mg/kg, 100 mg/l) had potent preventive effect and anti-tumor effect, macrophage phagocytosis and Con A-stimulated splenocyte proliferation were increased as compared with model control treatment. Bu-zhong-yi-qi wan could take part in the immune response by promoting the proliferation and differentiation of T-cells, increasing the activity of the macrophages, inducing the generation of cell factor IL-2, TNF-alpha, IFN-gamma. Conclusion: It proved that Bu-zhong-yi-qi wan of medium-dose had great preventive effect and could enhance immunity function.
学科主题	Integrative & Complementary Medicine
出版地	ILE-IFE
资助项目	国家科技支撑计划
项目编号	'Twelve Five'National Science and Technology Support Program [2011BAI05B02]
语种	英语
WOS记录号	WOS:000372927000008
资助机构	MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179534]
专题	药学院_期刊论文
通讯作者	Feng, SL (reprint author), Lanzhou Univ, Sch Pharm, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Hu, F,Liu, XY,Chen, XY,et al. THE PREVENTIVE EFFECT AND ENHANCE IMMUNITY FUNCTION OF BU-ZHONG-YI-QIWAN ON S180 TUMOR MICE[J]. AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES,2016,13(3):60-65.
APA	Hu, F.,Liu, XY.,Chen, XY.,Li, C.,Zhu, RJ.,...&Feng, SL .(2016).THE PREVENTIVE EFFECT AND ENHANCE IMMUNITY FUNCTION OF BU-ZHONG-YI-QIWAN ON S180 TUMOR MICE.AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES,13(3),60-65.
MLA	Hu, F,et al."THE PREVENTIVE EFFECT AND ENHANCE IMMUNITY FUNCTION OF BU-ZHONG-YI-QIWAN ON S180 TUMOR MICE".AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES 13.3(2016):60-65.