Reproductive factors and risk of type 2 diabetes in an occupational cohort of Chinese women

doi:10.1016/j.jdiacomp.2016.06.011

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	Reproductive factors and risk of type 2 diabetes in an occupational cohort of Chinese women
	Yang, AM; Liu, SM; Cheng, N; Pu, HQ; Dai, M; Ding, J; Li, JS; Li, HY; Hu, XB; Ren, XW
刊名	JOURNAL OF DIABETES AND ITS COMPLICATIONS
	2016-09-10
卷号	30 期号:7 页码:1217-1222
关键词	Menarche Menopause Type 2 diabetes Reproduction Risk factors
ISSN号	1056-8727
DOI	10.1016/j.jdiacomp.2016.06.011
文献子类	Article
英文摘要	Aims: Hormonal milieu has long been known to play an important role in the development of type 2 diabetes (T2D). The aims of this study are to investigate the roles of menstrual and reproductive factors in relation to T2D risk in an occupational cohort of Chinese women; and to explore the role of endogenous estrogen in T2D development. Methods: We conducted a cross-sectional analysis of baseline data from 16114 women (11051 premenopausal and 5063 postmenopausal) aged >= 20 years who participated in the ongoing prospective occupational cohort study. Multivariable logistic regressions were modeled to evaluate the associations of reproductive factors with T2D risk. Results: Early menarche at age (<= 12 versus 15-16 years) was associated with increased T2D risk (odds ratio [OR]: 1.60, 95% confidence interval [CI]: 1.16-2.22). After multiple adjustment including age, BMI and occupation, postmenopausal status was positively associated with T2D risk (OR: 1.54, 95% CI: 1.10-2.14). Reproductive life span was significantly associated with T2D risk (P = 0.02), albeit displaying a U-shape relationship. Similarly, age at menopause was also associated with T2D risk in the same U-shaped as with reproductive life span (P = 0.03). Further, years since menopause (P = 0.003), but not history of cycle regularity and hormone use, was associated with increased T2D risk. Conclusion: Reproductive factors were associated with T2D supporting the notion that either a short or prolonged exposure to endogenous estrogen affects T2D risk in Chinese women. Reproductive factors should be added to risk stratification when counseling women about their risk of developing diabetes. (C) 2016 Elsevier Inc. All rights reserved.
学科主题	Endocrinology & Metabolism
出版地	NEW YORK
资助项目	国家留学基金委项目 ; 美国国立卫生研究院项目
项目编号	US National Institutes of Health [D43TW 008323, D43TW 007864-01, DK66401] ; American Heart Association ; Project of Employees Health Status and Disease Burden Trend Study in Jinchang Nonferrous Metals Corporation [JKB20120013] ; China Scholarship Council [201406180021]
语种	英语
WOS记录号	WOS:000382097600003
资助机构	CSC ; NIH
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179635]
专题	公共卫生学院_期刊论文
通讯作者	Bai, YN (reprint author), Lanzhou Univ, Sch Publ Hlth, Dept Epidemiol & Stat, South Donggang Xi Rd 199, Lanzhou 730000, Gansu, Peoples R China.; Zheng, TZ (reprint author), Brown Univ, Sch Publ Hlth, Dept Epidemiol, 121 South Main St, Providence, RI 02912 USA.
推荐引用方式 GB/T 7714	Yang, AM,Liu, SM,Cheng, N,et al. Reproductive factors and risk of type 2 diabetes in an occupational cohort of Chinese women[J]. JOURNAL OF DIABETES AND ITS COMPLICATIONS,2016,30(7):1217-1222.
APA	Yang, AM.,Liu, SM.,Cheng, N.,Pu, HQ.,Dai, M.,...&Zheng, TZ .(2016).Reproductive factors and risk of type 2 diabetes in an occupational cohort of Chinese women.JOURNAL OF DIABETES AND ITS COMPLICATIONS,30(7),1217-1222.
MLA	Yang, AM,et al."Reproductive factors and risk of type 2 diabetes in an occupational cohort of Chinese women".JOURNAL OF DIABETES AND ITS COMPLICATIONS 30.7(2016):1217-1222.