Reporting quality of N-of-1 trials published between 1985 and 2013: a systematic review.

doi:10.1016/j.jclinepi.2015.11.016

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	Reporting quality of N-of-1 trials published between 1985 and 2013: a systematic review.
	Li, Jiang; Gao, Wei; Punja, Salima; Ma, Bin; Vohra, Sunita; Duan, Naihua; Gabler, Nicole; Yang, Kehu; Kravitz, Richard L; Yang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.
刊名	Journal of clinical epidemiology
	2016-08
卷号	76 页码:57-64
关键词	Single-patient (N-of-1) trials CONSORT guidelines Reporting quality Chronic Disease Therapy Comparative Effectiveness Research
ISSN号	1878-5921
DOI	10.1016/j.jclinepi.2015.11.016
文献子类	Article
英文摘要	Objectives: To evaluate the quality of reporting of single-patient (N-of-1) trials published in the medical literature based on the CONSORT Extension for N-of-1 Trials (CENT) statement and to examine factors that influence reporting quality in these trials. Study Design and Setting: Through a search of 10 electronic databases, we identified N-of-1 trials in clinical medicine published between January 1, 1985, and December 31, 2013. Two reviewers screened articles for eligibility and independently extracted data. Quality assessment was performed using the CENT statement. Discrepancies were resolved by consensus. Results: We identified 112 eligible N-of-1 trials published in 87 journals and involving a total of 2,278 patients. Overall, kappa agreement between the two evaluators for compliance with CENT criteria was 0.80 (95% confidence interval: 0.79, 0.82). Trials assessed pharmacology and therapeutics (87%), behavior (11%), or diagnosis (2%). Although 87% of articles described the trial design (including the planned number of subjects and length of treatment period), the median percentage of specific CENT elements reported in the Methods was 41% (range, 16-87%), and the median percentage in the Results was 38% (range, 32-93%). First authors were predominantly from North America (46%), Europe (29%), and Australia (17%). Quality of reporting was higher in articles published in journals with relatively high-impact factors (P = 0.004). Conclusion: The quality of reporting of published N-of-1 trials is variable and in need of improvement. Because the CENT guidelines were not published until near the end of the period of this review, these results represent a baseline from which improvement may be expected in the future. (C) 2016 Elsevier Inc. All rights reserved.
学科主题	Health Care Sciences & Services ; Public, Environmental & Occupational Health
出版地	NEW YORK
语种	英语
WOS记录号	WOS:000385212500007
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179134]
专题	基础医学院_期刊论文
通讯作者	Yang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.; Yang, KH (reprint author), Key Lab Evidence Based Med & Knowledge Translat G, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.; Kravitz, RL (reprint author), Univ Calif Davis, Dept Internal Med, 4150 5 St,Suite 2400 PSSB, Sacramento, CA 95817 USA.; Kravitz, RL (reprint author), Univ Calif Davis, Ctr Healthcare Policy & Res, 4150 5 St,Suite 2400 PSSB, Sacramento, CA 95817 USA.
推荐引用方式 GB/T 7714	Li, Jiang,Gao, Wei,Punja, Salima,et al. Reporting quality of N-of-1 trials published between 1985 and 2013: a systematic review.[J]. Journal of clinical epidemiology,2016,76:57-64.
APA	Li, Jiang.,Gao, Wei.,Punja, Salima.,Ma, Bin.,Vohra, Sunita.,...&Kravitz, RL .(2016).Reporting quality of N-of-1 trials published between 1985 and 2013: a systematic review..Journal of clinical epidemiology,76,57-64.
MLA	Li, Jiang,et al."Reporting quality of N-of-1 trials published between 1985 and 2013: a systematic review.".Journal of clinical epidemiology 76(2016):57-64.