Catalytic Asymmetric Ring-Opening Reactions of Aziridines with 3-Aryl-Oxindoles

doi:10.1002/asia.201501369

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	Catalytic Asymmetric Ring-Opening Reactions of Aziridines with 3-Aryl-Oxindoles
	Wang, LQ; Li, D; Yang, DX; Wang, KZ; Wang, J; Wang, PX; Su, W; Wang, R; Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.; Su, W (reprint author), Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Guangdong Key Lab Nanomed, Shenzhen 518055, Guangdong, Peoples R China.
刊名	CHEMISTRY-AN ASIAN JOURNAL
	2016-03-04
卷号	11 期号:5 页码:691-695
关键词	aziridines 3,3 '-fluorinated-binol magnesium catalysis oxindoles ring-opening reactions
ISSN号	1861-4728
DOI	10.1002/asia.201501369
文献子类	Article
英文摘要	A highly enantioselective ring-opening alkylation reaction between 3-aryl-oxindole and N-(2-picolinoyl) aziridine has been realized for the first time. The reaction is efficiently mediated by a simple in-situ-generated magnesium catalyst and 3,3-fluorinated-BINOL (BINOL=1,1-binaphthalene-2,2-diol) has been identified as a powerful chiral ligand. Notably, the fluorine atom on the chiral ligand plays a key role in providing the desired chiral 3-alkyl-3-aryl oxindoles with excellent enantioselectivities.
学科主题	Chemistry
出版地	WEINHEIM
资助项目	国家自然科学基金项目 ; 长江学者和创新团队发展计划 ; 中央高校基本科研业务费专项资金 ; 甘肃省创新研究群体计划
项目编号	NSFC [91413107, 21432003, 91213302, 81473095, 21272102] ; Program for Chang-jiang Scholars and Innovative Research Team in University [PCSIRT: IRT1137] ; Innovation Group of Gansu Province [1210RJIA002] ; Fundamental Research Funds for the Central Universities [lzujbky-2015-282]
语种	英语
WOS记录号	WOS:000372184600009
资助机构	NSFC ; MOE ; LZU ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179103]
专题	基础医学院_期刊论文
通讯作者	Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.; Su, W (reprint author), Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Guangdong Key Lab Nanomed, Shenzhen 518055, Guangdong, Peoples R China.; Wang, R (reprint author), Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China.
推荐引用方式 GB/T 7714	Wang, LQ,Li, D,Yang, DX,et al. Catalytic Asymmetric Ring-Opening Reactions of Aziridines with 3-Aryl-Oxindoles[J]. CHEMISTRY-AN ASIAN JOURNAL,2016,11(5):691-695.
APA	Wang, LQ.,Li, D.,Yang, DX.,Wang, KZ.,Wang, J.,...&Wang, R .(2016).Catalytic Asymmetric Ring-Opening Reactions of Aziridines with 3-Aryl-Oxindoles.CHEMISTRY-AN ASIAN JOURNAL,11(5),691-695.
MLA	Wang, LQ,et al."Catalytic Asymmetric Ring-Opening Reactions of Aziridines with 3-Aryl-Oxindoles".CHEMISTRY-AN ASIAN JOURNAL 11.5(2016):691-695.