The Effect of Calcium Sodium Phosphosilicate on Dentin Hypersensitivity: A Systematic Review and Meta-Analysis

doi:10.1371/journal.pone.0140176

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	The Effect of Calcium Sodium Phosphosilicate on Dentin Hypersensitivity: A Systematic Review and Meta-Analysis
	Zhu, MJ; Li, JL; Chen, B; Mei, L; Yao, L; Tian, JH; Li, H; Li, H (reprint author), Nanjing Univ, Sch Med, Nanjing Stomatol Hosp, Dept Oral Sci, Nanjing, Jiangsu, Peoples R China.
刊名	PLOS ONE
	2015-11-06
卷号	10 期号:11
ISSN号	1932-6203
DOI	10.1371/journal.pone.0140176
文献子类	Article
英文摘要	Objective To investigate the effect of calcium sodium phosphosilicate (CSPS) in treating dentin hypersensitivity (DH) and to compare this effect to that of a negative (placebo) control. Materials and Methods Several databases, including Medline, EMBASE, Web of Science, The Cochrane Library, and the Chinese Biomedical Literature Database, were searched to identify relevant articles published through January 2015; grey literature (i.e., academic literature that is not formally published) was also searched. Two authors performed data extraction independently and jointly using data collection forms. The primary outcome was the DH pain response to routine activities or to thermal, tactile, evaporative, or electrical stimuli, and the secondary outcome was the side effects of CSPS use. Each study was evaluated using the Cochrane Collaboration tool for assessing risk bias. Meta-analysis of studies with the same participant demographics, interventions, controls, assessment methods and follow-up periods was performed. The Grading of Recommendations Assessment Development and Evaluation System was used to assess the quality of the evidence and the risk of bias across studies. Results Meta-analysis demonstrated that toothpaste containing 5% CSPS was more effective than the negative control at relieving dentin sensitivity, with the level of evidence classified as "moderate". In addition, prophylaxis paste containing 15% calcium sodium phosphosilicate was favored over the negative control at reducing post-periodontal therapy hypersensitivity, with the level of evidence categorized as "low". Only two studies reported side effects of CSPS use. Conclusions The majority of studies found that calcium sodium phosphosilicate was more effective than the negative control at alleviating DH. Because strong evidence is scarce, high-quality, well-designed clinical trials are required in the future before definitive recommendations can be made.
学科主题	Science & Technology - Other Topics
出版地	SAN FRANCISCO
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [81470712, 81070807]
语种	英语
WOS记录号	WOS:000364398700005
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179076]
专题	基础医学院_期刊论文
通讯作者	Li, H (reprint author), Nanjing Univ, Sch Med, Nanjing Stomatol Hosp, Dept Oral Sci, Nanjing, Jiangsu, Peoples R China.
推荐引用方式 GB/T 7714	Zhu, MJ,Li, JL,Chen, B,et al. The Effect of Calcium Sodium Phosphosilicate on Dentin Hypersensitivity: A Systematic Review and Meta-Analysis[J]. PLOS ONE,2015,10(11).
APA	Zhu, MJ.,Li, JL.,Chen, B.,Mei, L.,Yao, L.,...&Li, H .(2015).The Effect of Calcium Sodium Phosphosilicate on Dentin Hypersensitivity: A Systematic Review and Meta-Analysis.PLOS ONE,10(11).
MLA	Zhu, MJ,et al."The Effect of Calcium Sodium Phosphosilicate on Dentin Hypersensitivity: A Systematic Review and Meta-Analysis".PLOS ONE 10.11(2015).