Effect of ephedrine on intubating conditions created by propofol and rocuronium: a meta-analysis

doi:10.1111/jebm.12003

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	Effect of ephedrine on intubating conditions created by propofol and rocuronium: a meta-analysis
	Sun, Rao; Tian, Jin Hui; Li, Lun; Tian, Hong Liang; Jia, Wen Qin; Yang, Ke Hu; Cao, Nong
刊名	Journal of evidence-based medicine
	2012-11
卷号	5 期号:4 页码:209-215
关键词	Adrenergic Agents Administration & Dosage Androstanols Administration & Dosage Administration & Dosage Anesthetics Intravenous Drug Administration Schedule Dose-response Relationship Ephedrine Drug Administration & Dosage Humans Methods Intubation Intratracheal Neuromuscular Nondepolarizing Agents Models Administration & Dosage Statistical Outcome Assessment (Health Care) Propofol Administration & Dosage Randomized Controlled Trials As Topic
ISSN号	1756-5391
DOI	10.1111/jebm.12003
英文摘要	2012 Wiley Publishing Asia Pty Ltd and Chinese Cochrane Center, West China Hospital of Sichuan University.OBJECTIVE: To evaluate the effect of ephedrine on intubation conditions (ICs) one minute after anesthesia induction using propofol and rocuronium.METHODS: PubMed, EMbase, The Cochrane Library, ISI Web of Knowledge, Chinese Biomedical Literature Database, Google Scholar, and other databases were searched from inception to September 2012 to collect relevant randomized clinical trials (RCTs). We evaluated the risk of bias of the included studies by the Cochrane Collaboration's risk of bias tool and analyzed the data using RevMan 5.1. As the outcomes, excellent ICs, clinically acceptable ICs and side effects were evaluated with risk ratios (RRs).RESULTS: Five RCTs involving 396 patients were identified. The results of the meta-analysis demonstrated that ephedrine increased the rate of excellent ICs (RR = 2.40, 95% CI 1.89 to 3.05), but had no effects on the rate of clinically acceptable ICs (RR = 1.15, 95% CI 0.93 to 1.42) and the incidence of side effects (RR = 2.00, 95% CI 0.19 to 21.36). Besides, the results of subgroup analysis showed that both low dose and high dose of ephedrine increased the rate of excellent ICs, but only low dose increased the rate of clinically acceptable ICs. The results of sensitive analysis showed that both favored ephedrine (excellent ICs: RR = 2.54, 95% CI 1.69 to 3.83; clinically acceptable ICs: RR = 1.21, 95% CI 1.07 to 1.38).CONCLUSION: Ephedrine, without extra side effects, created superior ICs one minute after anesthesia induction using propofol and rocuronium, and low dose (i.e., 70-100 mug/kg) is recommended as the possible optimal dose.
学科主题	Pharmacology & Pharmacy ; Biochemistry & Molecular Biology ; Anesthesiology ; Health Care Sciences & Services
语种	英语
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/163611]
专题	基础医学院_期刊论文
推荐引用方式 GB/T 7714	Sun, Rao,Tian, Jin Hui,Li, Lun,et al. Effect of ephedrine on intubating conditions created by propofol and rocuronium: a meta-analysis[J]. Journal of evidence-based medicine,2012,5(4):209-215.
APA	Sun, Rao.,Tian, Jin Hui.,Li, Lun.,Tian, Hong Liang.,Jia, Wen Qin.,...&Cao, Nong.(2012).Effect of ephedrine on intubating conditions created by propofol and rocuronium: a meta-analysis.Journal of evidence-based medicine,5(4),209-215.
MLA	Sun, Rao,et al."Effect of ephedrine on intubating conditions created by propofol and rocuronium: a meta-analysis".Journal of evidence-based medicine 5.4(2012):209-215.