HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China

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	HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China
	Li, FR; Shi, YE; Shi, DZ; Vuitton, DA; Craig, PS; Li, FR (reprint author), Jinan Univ, Affiliated Hsop 2, Clin Med Res Ctr, Shenzhen Peoples Hosp, Shenzhen 518020, Peoples R China.
刊名	CHINESE MEDICAL JOURNAL
	2003-10
卷号	116 期号:10 页码:1557-1560
关键词	HLA-DR antigens echincoccosis polymerase chain reaction
ISSN号	0366-6999
文献子类	Article
英文摘要	Objective. To investigate the association between histocompatibility leukocyte antigen (HLA)-DRB1 alleles and alveolar echinococcosis (AE). Methods. Thirty-five patients with AE in high prevalence areas in Gansu Province of China were tested for the HLA-DRB1 gene using the polymerase chain reaction with sequence-specific primer (PCR-SSP) technique. The results were compared with those of 104 healthy individuals. Results. The frequency of the HLA-DRB1 * 040x gene was 26% in the patient group, which was significantly higher than that in the control group (9.62%) with a relative risk (RR) of 4.45 (chi(2) = 13.67, P < 0.01), and an etiological fraction (EF) of 0.20. The frequency of the HLA-DRB1 0701 allele was significantly lower in the patient group (2.86%) as compared to the control group (13.94%; chi(2) = 6.67, P < 0.05) with a preventable fraction (PF) of 0.30. The frequencies of other DRB1 alleles were not significantly different. Conclusion. Susceptibility to AE is significantly associated with the HLA-DRB1 * 040x. HLA-DRB1 * 0701 gene might confer protection against AE in humans.
学科主题	General & Internal Medicine
出版地	BEIJING
语种	英语
WOS记录号	WOS:000186675900028
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121335]
专题	基础医学院_期刊论文
通讯作者	Li, FR (reprint author), Jinan Univ, Affiliated Hsop 2, Clin Med Res Ctr, Shenzhen Peoples Hosp, Shenzhen 518020, Peoples R China.
推荐引用方式 GB/T 7714	Li, FR,Shi, YE,Shi, DZ,et al. HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China[J]. CHINESE MEDICAL JOURNAL,2003,116(10):1557-1560.
APA	Li, FR,Shi, YE,Shi, DZ,Vuitton, DA,Craig, PS,&Li, FR .(2003).HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China.CHINESE MEDICAL JOURNAL,116(10),1557-1560.
MLA	Li, FR,et al."HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China".CHINESE MEDICAL JOURNAL 116.10(2003):1557-1560.