Effects of recombinant human basic fibroblast growth factor on restenosis after arterial endothelial injury in rats

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	Effects of recombinant human basic fibroblast growth factor on restenosis after arterial endothelial injury in rats
	Chang, L; Zhang, C; Wu, YJ; Zhu, RZ; Wu, YJ (reprint author), Lanzhou Med Coll, Dept Pharmacol, Lanzhou 730000, Peoples R China.
刊名	ACTA PHARMACOLOGICA SINICA
	2001-10
卷号	22 期号:10 页码:876-880
关键词	percutaneous coronary transluminal angioplasty basic fibroblast growth factor vascular smooth muscle 经皮冠状动脉经腔血管成形术碱性成纤维细胞生长因子血管平滑肌
ISSN号	0253-9756
其他题名	重组人碱性成纤维细胞生长因子对大鼠动脉内皮损伤后再狭窄的影响(英文)
文献子类	Article
英文摘要	Aim: To study the preventive effect of recombinant human basic fibroblast growth factor ( rh-bFGF) on restenosis after percutaneous transluminal coronary angioplasty (PTCA). Methods: Sixty male Wistar rats were randomly divided into sham operation group, intima. injured group, and intima injured plus rh-bFGF treated group. Rat carotid arteries were injured using a balloon catheter except sham operation group. The rats of rh-bFGF treated group were injected im rh-bFGF 10 kU.g(-1).d(-1) after intima was injured. Ten rats in each group were killed on d 7 and d 14 after injury, respectively. [H-3] Thymidine incorporation assay and pathological examination were carried out to each vessel. Results: (1) Seven days after injury, the average intimal. thickness in sham operation group, intima. injured group, and rh-bFGF treated group was (7 1), (32 +/- 11), and (17 +/-3) mum; average intimal area was (384 +/- 145), ( 1530 +/- 817), and (586 +/- 185) mum(2); the numbers of smooth muscle cells in neointima per transect were 0 +/-0, 146 +/- 18, and 105 +/- 26; the ratio of the collagen area to intimal area plus medial area were 0.29 +/-0.09, 0.7 +/-0.3, and 0.30 +/-0.14; [H-3] thymidine incorporation were (17 +/-6), (62 +/- 23), (20 +/-8) kBq/g tissue, respectively. (2) Fourteen days after injury, the average intimal thickness of sham operation group, intima injured group, and rh-bFGF treated group was (8 +/-1), (41 +/-9), and (20 +/-3) tan; average intimal area was (391 +/- 134), (1761 +/- 337), and (731 +/- 124) mum(2); the numbers of smooth muscle cells in neointima per transect were 0 +/-0, 145 +/-9, and 102 +/-6; the ratio of collagen area to intimal area plus medial area were 0.28 +/-0.14, 0.59 +/-0.21, and 0.38 +/-0.03; [H-3] thymidine incorporation was (15 +/-4), (57 +/- 11), and (22 +/-6) kBq/g tissue, respectively. Conclusion: Large dosage of rh-bFGF inhibits neointimal hyperplasia and reduces restenosis after balloon injury.
学科主题	Chemistry ; Pharmacology & Pharmacy
出版地	SHANGHAI
语种	英语
CSCD记录号	CSCD:515901
WOS记录号	WOS:000171407600003
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121318]
专题	基础医学院_期刊论文
通讯作者	Wu, YJ (reprint author), Lanzhou Med Coll, Dept Pharmacol, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Chang, L,Zhang, C,Wu, YJ,et al. Effects of recombinant human basic fibroblast growth factor on restenosis after arterial endothelial injury in rats[J]. ACTA PHARMACOLOGICA SINICA,2001,22(10):876-880.
APA	Chang, L,Zhang, C,Wu, YJ,Zhu, RZ,&Wu, YJ .(2001).Effects of recombinant human basic fibroblast growth factor on restenosis after arterial endothelial injury in rats.ACTA PHARMACOLOGICA SINICA,22(10),876-880.
MLA	Chang, L,et al."Effects of recombinant human basic fibroblast growth factor on restenosis after arterial endothelial injury in rats".ACTA PHARMACOLOGICA SINICA 22.10(2001):876-880.