Effects of 2.5 s mouse nerve growth factor on regeneration of injured sciatic nerves in mice and rats

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	Effects of 2.5 s mouse nerve growth factor on regeneration of injured sciatic nerves in mice and rats
	Wang, JZ; Bai, DC; Rao, CM; Li, WG; Gao, MT; Wang, XQ; Wu, YJ; Wang, JZ (reprint author), NATL INST CONTROL PHARMACEUT & BIOL PROD,BEIJING 100050,PEOPLES R CHINA.
刊名	ACTA PHARMACOLOGICA SINICA
	1997-11
卷号	18 期号:6 页码:501-&
关键词	nerve growth factors 神经生长因子 nerve regeneration 神经再生 sciatic nerve 坐骨神经 nerve crush 神经损伤 skeletal muscle 骨骼肌 neural conduction 神经传导
ISSN号	0253-9756
其他题名	小鼠2.5s神经生物因子对大鼠和小鼠受损坐骨神经再生的影响
文献子类	Article
英文摘要	AIM: To study the promoting activity of 2.5 s murine nerve growth factor (NGF) for the regeneration of injuried sciatic nerve. METHODS: The sciatic nerves of mice and rats were crushed. The axon counts and differential axon counts were made. Evoked potential latency (NMEPL) was recorded at sites of proximal (Pro) and distal (Dis) segment of soleus muscles. RESULTS: In mice, NGF im 0.5 - 1 kBU . kg(-1) increased the axon counts of regenerated nerves 20 d after crush; 2 - 4 kBU . kg(-1) simultaneously alleviated the denervated atrophy of soleus muscles. In rats, NGF im increased the axon counts at dose of 1 kBU . kg(-1) for 40 d, 2 kBU . kg(-1) for 30 d and 40 d, and 4 kBU . kg(-1) for 20 d, 30 d and 40 d after crush; the number of large axons of regenerated nerves were also increased by NGF im 2 kBU . kg(-1) for 40 d and 4 kBU . kg(-1) for 30 d and 40 d; Pro NMEPL was shortened by NGF 1, 2, and 4 kBU . kg(-1), Dis-NMEPL was shortened by NGF 2 and 4 kBU . kg(-1) for 40 d. CONCLUSION: NGF im evidently promotes the regeneration of injuried sciatic nerve, and attenuates the skeletal muscular atrophy caused by nerve injury.
学科主题	Chemistry ; Pharmacology & Pharmacy
出版地	SHANGHAI
语种	英语
CSCD记录号	CSCD:411813
WOS记录号	WOS:A1997YE13600006
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121305]
专题	基础医学院_期刊论文
通讯作者	Wang, JZ (reprint author), NATL INST CONTROL PHARMACEUT & BIOL PROD,BEIJING 100050,PEOPLES R CHINA.
推荐引用方式 GB/T 7714	Wang, JZ,Bai, DC,Rao, CM,et al. Effects of 2.5 s mouse nerve growth factor on regeneration of injured sciatic nerves in mice and rats[J]. ACTA PHARMACOLOGICA SINICA,1997,18(6):501-&.
APA	Wang, JZ.,Bai, DC.,Rao, CM.,Li, WG.,Gao, MT.,...&Wang, JZ .(1997).Effects of 2.5 s mouse nerve growth factor on regeneration of injured sciatic nerves in mice and rats.ACTA PHARMACOLOGICA SINICA,18(6),501-&.
MLA	Wang, JZ,et al."Effects of 2.5 s mouse nerve growth factor on regeneration of injured sciatic nerves in mice and rats".ACTA PHARMACOLOGICA SINICA 18.6(1997):501-&.