A viscoelastic-stochastic model of the effects of cytoskeleton remodelling on cell adhesion

doi:10.1098/rsos.160539

	A viscoelastic-stochastic model of the effects of cytoskeleton remodelling on cell adhesion
	Li, L; Zhang, WY; Wang, JZ; Wang, JZ (reprint author), Lanzhou Univ, Coll Civil Engn & Mech, Key Lab Mech Disaster & Environm inWestern China, Minist Educ, Lanzhou 730000, Gansu, Peoples R China.
刊名	ROYAL SOCIETY OPEN SCIENCE
	2016-10
卷号	3 期号:1-10
关键词	cell adhesion viscoelastic-stochastic model Monte Carlo simulation
ISSN号	2054-5703
DOI	10.1098/rsos.160539
文献子类	Article
英文摘要	Cells can adapt their mechanical properties through cytoskeleton remodelling in response to external stimuli when the cells adhere to the extracellular matrix (ECM). Many studies have investigated the effects of cell and ECM elasticity on cell adhesion. However, experiments determined that cells are viscoelastic and exhibiting stress relaxation, and the mechanism behind the effect of cellular viscoelasticity on the cell adhesion behaviour remains unclear. Therefore, we propose a theoretical model of a cluster of ligand-receptor bonds between two dissimilar viscoelastic media subjected to an applied tensile load. In this model, the distribution of interfacial traction is assumed to follow classical continuum viscoelastic equations, whereas the rupture and rebinding of individual molecular bonds are governed by stochastic equations. On the basis of this model, we determined that viscosity can significantly increase the lifetime, stability and dynamic strength of the adhesion cluster of molecular bonds, because deformation relaxation attributed to the viscoelastic property can increase the rebinding probability of each open bond and reduce the stress concentration in the adhesion area.
学科主题	Science & Technology - Other Topics
出版地	LONDON
资助项目	国家自然科学基金项目 ; 中央高校基本科研业务费专项资金
项目编号	National Natural Science Foundation of China [11472119] ; Innovative Research Group of the National Natural Science Foundation of China [11421062] ; Fundamental Research Funds for the Central Universities [lzujbky-2015-299]
语种	英语
WOS记录号	WOS:000389241700042
资助机构	NSFC ; LZU
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/189430]
专题	土木工程与力学学院_期刊论文
通讯作者	Wang, JZ (reprint author), Lanzhou Univ, Coll Civil Engn & Mech, Key Lab Mech Disaster & Environm inWestern China, Minist Educ, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Li, L,Zhang, WY,Wang, JZ,et al. A viscoelastic-stochastic model of the effects of cytoskeleton remodelling on cell adhesion[J]. ROYAL SOCIETY OPEN SCIENCE,2016,3(1-10).
APA	Li, L,Zhang, WY,Wang, JZ,&Wang, JZ .(2016).A viscoelastic-stochastic model of the effects of cytoskeleton remodelling on cell adhesion.ROYAL SOCIETY OPEN SCIENCE,3(1-10).
MLA	Li, L,et al."A viscoelastic-stochastic model of the effects of cytoskeleton remodelling on cell adhesion".ROYAL SOCIETY OPEN SCIENCE 3.1-10(2016).