Characterization and Insights Into the Nano Liposomal Magnetic Gene Vector Used for Cell Co-Transfection

doi:10.1166/jnn.2015.10048

CORC > 中国农业科学院 > 农业环境与可持续发展研究所 > 环境工程研究室

	Characterization and Insights Into the Nano Liposomal Magnetic Gene Vector Used for Cell Co-Transfection
	Chen, Wenjie 1,2; Cui, Haixin 1,2; Zhao, Xiang 1,2; Cui, Jinhui 3; Wang, Yan 1,2; Sun, Chaojiao 1,2; Cui, Bo 1,2; Lei, Feng 1,2
刊名	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
	2015
卷号	15 期号:8 页码:5530-5536
关键词	Liposomal Magnetofection Magnetic Nanoparticles Co-Transfection Atomic Force Microscopy
ISSN号	1533-4880
DOI	10.1166/jnn.2015.10048
通讯作者	Chen, Wenjie
英文摘要	The development of magnetofection technology has brought a promising method for gene delivery. Here, we develop a novel liposomal magnetofection system, consisted of magnetic nanoparticle and liposome through molecular assembly, was applied to introduce double genes into porcin somatic cells with high co-transfection efficiency. The performace of liposomal magnetic gene nanovectors has been evaluated by involving the micro morphology, diameters distribution, zeta potentials and the capacity of loading DNA molecules. The assembly way among magnetic gene nanovectors and DNA molecules was investigated by atomic force microscopy. Liposomal nano magnetic gene vectors complexes displayed nanoscale assembly and formed compact "fishing-net structure" after combining with plasmid DNA, which is favorable to enhance the loading capacity of DNA molecules.
学科主题	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
WOS记录号	WOS:000350268100006
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/19747]
专题	农业环境与可持续发展研究所_环境工程研究室
作者单位	1.Chinese Acad Agr Sci, Inst Environm & Sustainable Dev Agr, Beijing 100081, Peoples R China 2.Chinese Acad Agr Sci, Nano Biol Res Ctr, Beijing 100081, Peoples R China 3.Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Chen, Wenjie,Cui, Haixin,Zhao, Xiang,et al. Characterization and Insights Into the Nano Liposomal Magnetic Gene Vector Used for Cell Co-Transfection[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2015,15(8):5530-5536.
APA	Chen, Wenjie.,Cui, Haixin.,Zhao, Xiang.,Cui, Jinhui.,Wang, Yan.,...&Lei, Feng.(2015).Characterization and Insights Into the Nano Liposomal Magnetic Gene Vector Used for Cell Co-Transfection.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,15(8),5530-5536.
MLA	Chen, Wenjie,et al."Characterization and Insights Into the Nano Liposomal Magnetic Gene Vector Used for Cell Co-Transfection".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 15.8(2015):5530-5536.