Microwave assisted synthesis, antifungal activity, DFT and SAR study of 1,2,4-triazolo[4,3-a]pyridine derivatives containing hydrazone moieties

doi:10.1186/s13065-016-0196-6

	Microwave assisted synthesis, antifungal activity, DFT and SAR study of 1,2,4-triazolo[4,3-a]pyridine derivatives containing hydrazone moieties
	Mu, Jin-Xia 1; Shi, Yan-Xia 3; Wu, Hong-Ke 2; Sun, Zhao-Hui 2; Yang, Ming-Yan 2; Liu, Xing-Hai 2; Li, Bao-Ju 3
刊名	CHEMISTRY CENTRAL JOURNAL
	2016
卷号	10 页码:-
关键词	1,2,4-Triazolo[4,3-a]pyridine Hydrazone Microwave assisted synthesis Antifungal activity DFT
ISSN号	1752-153X
DOI	10.1186/s13065-016-0196-6
通讯作者	Mu, Jin-Xia
英文摘要	Background: The increasing prevalence of multi-drug resistant fungal infections has encouraged the search for new antifungal agents. Hydrazone derivatives always exhibited diversity activities, including antifungal, anti-inflammatory, anti-oxidation, anti-cancer activity. Regarding the heterocyclic moiety, 1,2,4-triazolo[4,3-a]pyridine derivatives also display broad activities, such as antifungal activity, anticonvulsant activity, herbicidal activity, antimicrobial activity and anticancer activity.Results: A series of novel 1,2,4-triazolo[4,3-a]pyridine derivatives containing hydrazone moiety were designed and synthesized from 2,3-dichloropyridine, hydrazine hydrate by multi-step reactions under microwave irradiation condition, and their structures were characterized by FT IR, H-1 NMR, C-13 NMR, F-19 NMR, MS and elemental analysis. The antifungal activities of title compounds were determined. The results indicated that some of the title compounds exhibited good antifungal activity. Furthermore, DFT calculation was carried out for studying the structure-activity relationship (SAR).Conclusion: A practical synthetic route to obtain 1,2,4-triazolo[4,3-a]pyridine derivatives is presented. This study suggests that the 1,2,4-triazolo[4,3-a]pyridine derivatives exhibited good antifungal activity.
学科主题	Chemistry, Multidisciplinary
语种	英语
出版者	BIOMED CENTRAL LTD
WOS记录号	WOS:000381572600002
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/105915]
专题	蔬菜花卉研究所_植物保护研究室
作者单位	1.China Jiliang Univ, Dept Environm Engn, Hangzhou 310018, Zhejiang, Peoples R China 2.Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China 3.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100014, Peoples R China
推荐引用方式 GB/T 7714	Mu, Jin-Xia,Shi, Yan-Xia,Wu, Hong-Ke,et al. Microwave assisted synthesis, antifungal activity, DFT and SAR study of 1,2,4-triazolo[4,3-a]pyridine derivatives containing hydrazone moieties[J]. CHEMISTRY CENTRAL JOURNAL,2016,10:-.
APA	Mu, Jin-Xia.,Shi, Yan-Xia.,Wu, Hong-Ke.,Sun, Zhao-Hui.,Yang, Ming-Yan.,...&Li, Bao-Ju.(2016).Microwave assisted synthesis, antifungal activity, DFT and SAR study of 1,2,4-triazolo[4,3-a]pyridine derivatives containing hydrazone moieties.CHEMISTRY CENTRAL JOURNAL,10,-.
MLA	Mu, Jin-Xia,et al."Microwave assisted synthesis, antifungal activity, DFT and SAR study of 1,2,4-triazolo[4,3-a]pyridine derivatives containing hydrazone moieties".CHEMISTRY CENTRAL JOURNAL 10(2016):-.