Synthesis of Some N, N'-Diacylhydrazine Derivatives with Radical-Scavenging and Antifungal Activity

doi:10.1111/j.1747-0285.2009.00779.x

	Synthesis of Some N, N'-Diacylhydrazine Derivatives with Radical-Scavenging and Antifungal Activity
	Liu, Xing-Hai 1; Shi, Yan-Xia 2; Ma, Yi 1; He, Guo-Rong 3,4; Dong, Wei-Li 1; Zhang, Chuan-Yu 1; Wang, Bao-Lei 1; Wang, Su-Hua 1; Li, Bao-Ju 2; Li, Zheng-Ming 1
刊名	CHEMICAL BIOLOGY & DRUG DESIGN
	2009
卷号	73 期号:3 页码:320-327
关键词	1 1-diphenyl-2-picrylhydrazyl radical-scavenging activity antifungal activities comparative molecular field analysis diacylhydrazines
ISSN号	1747-0277
DOI	10.1111/j.1747-0285.2009.00779.x
通讯作者	Liu, Xing-Hai
英文摘要	A series of N,N'-diacylhydrazines were prepared and their structures were confirmed by (1)H NMR, MS and FTICR-MS. They were tested radical-scavenging activity in vitro. The preliminary bioassays of title compounds showed that two compounds had excellent radical-scavenging activity comparable with vitamin C, while the activity is highly relative to the substituents. Surprisingly, several compounds also exhibit favorable fungicidal activities. To further explore the comprehensive structure-activity relationships about the fungicidal activity, a three-dimensional quantitative structure-activity relationship analysis using the method of comparative molecular field analysis was performed.
学科主题	Biochemistry & Molecular Biology ; Chemistry, Medicinal ; BIOCHEMISTRY & MOLECULAR BIOLOGY ; CHEMISTRY, MEDICINAL
语种	英语
出版者	WILEY-BLACKWELL PUBLISHING, INC
WOS记录号	WOS:000263136600007
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/101213]
专题	蔬菜花卉研究所_植物保护研究室
作者单位	1.Nankai Univ, State Key Lab Elementoorg Chem, Natl Pesticide Engn Res Ctr Tianjin, Tianjin 300071, Peoples R China 2.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China 3.Chinese Acad Med Sci, Natl Ctr Pharmaceut Screening, Inst Mat Med, Beijing 100050, Peoples R China 4.Peking Union Med Coll, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xing-Hai,Shi, Yan-Xia,Ma, Yi,et al. Synthesis of Some N, N'-Diacylhydrazine Derivatives with Radical-Scavenging and Antifungal Activity[J]. CHEMICAL BIOLOGY & DRUG DESIGN,2009,73(3):320-327.
APA	Liu, Xing-Hai.,Shi, Yan-Xia.,Ma, Yi.,He, Guo-Rong.,Dong, Wei-Li.,...&Li, Zheng-Ming.(2009).Synthesis of Some N, N'-Diacylhydrazine Derivatives with Radical-Scavenging and Antifungal Activity.CHEMICAL BIOLOGY & DRUG DESIGN,73(3),320-327.
MLA	Liu, Xing-Hai,et al."Synthesis of Some N, N'-Diacylhydrazine Derivatives with Radical-Scavenging and Antifungal Activity".CHEMICAL BIOLOGY & DRUG DESIGN 73.3(2009):320-327.