Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3, 4-thiadiazol-2-yl)cyclopropanecarboxamides | |
Liu, Xing-Hai2; Shi, Yan-Xia1; Ma, Yi2; Zhang, Chuan-Yu2; Dong, Wei-Li2; Pan, Li2; Wang, Bao-Lei2; Li, Bao-Ju1; Li, Zheng-Ming2 | |
刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY |
2009 | |
卷号 | 44期号:7页码:2782-2786 |
关键词 | Cyclopropanecarboxamide 1,3,4-Thiadiazole Antifungal activity 3D-QSAR Synthesis |
ISSN号 | 0223-5234 |
DOI | 10.1016/j.ejmech.2009.01.012 |
通讯作者 | Liu, Xing-Hai |
英文摘要 | A series of cyclopropanecarboxamide were prepared and tested for antifungal activity in vivo. The preliminary bioassays indicated that some compounds are comparable to the commercial fungicides. To further explore the comprehensive structure-activity relationship on the basis of fungicidal activity data, comparative molecular field analysis (CoMFA) was performed, and a statistically reliable model with good predictive power (r(2) = 0.8, q(2) = 0.516) was achieved. Based on the CoMFA, compound 7p was designed and synthesized, which was found to display a good antifungal activity (79.38%) as 7g and 7h. (C) 2009 Elsevier Masson SAS. All rights reserved. |
学科主题 | Chemistry, Medicinal ; CHEMISTRY, MEDICINAL |
语种 | 英语 |
出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
WOS记录号 | WOS:000266524900003 |
内容类型 | 期刊论文 |
源URL | [http://111.203.20.206/handle/2HMLN22E/101989] |
专题 | 蔬菜花卉研究所 |
作者单位 | 1.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing, Peoples R China 2.Nankai Univ, Tianjin Key Lab Pesticide Sci, Natl Pesticidal Engn Ctr Tianjin, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Xing-Hai,Shi, Yan-Xia,Ma, Yi,et al. Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3, 4-thiadiazol-2-yl)cyclopropanecarboxamides[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2009,44(7):2782-2786. |
APA | Liu, Xing-Hai.,Shi, Yan-Xia.,Ma, Yi.,Zhang, Chuan-Yu.,Dong, Wei-Li.,...&Li, Zheng-Ming.(2009).Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3, 4-thiadiazol-2-yl)cyclopropanecarboxamides.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,44(7),2782-2786. |
MLA | Liu, Xing-Hai,et al."Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3, 4-thiadiazol-2-yl)cyclopropanecarboxamides".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 44.7(2009):2782-2786. |
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