Origin, inheritance, and gene regulatory consequences of genome dominance in polyploids

doi:10.1073/pnas.1402475111

CORC > 中国农业科学院 > 蔬菜花卉研究所

	Origin, inheritance, and gene regulatory consequences of genome dominance in polyploids
	Woodhouse, Margaret R.1; Cheng, Feng 1,2; Pires, J. Chris 3; Lisch, Damon 1; Freeling, Michael 1; Wang, Xiaowu 2
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2014
卷号	111 期号:14 页码:5283-5288
关键词	Brassica epigenetics
ISSN号	0027-8424
DOI	10.1073/pnas.1402475111
通讯作者	Woodhouse, Margaret R.
英文摘要	Whole-genome duplications happen repeatedly in a typical flowering plant lineage. Following most ancient tetraploidies, the two subgenomes are distinguishable because one subgenome, the dominant subgenome, tends to have more genes than the other subgenome. Additionally, among retained pairs, the gene on the dominant subgenome tends to be expressed more than its recessive homeolog. Using comparative genomics, we show that genome dominance is heritable. The dominant subgenome of one postpolyploidy event remains dominant through a subsequent polyploidy event. We show that transposon-derived 24-nt RNAs target and cover the upstream region of retained genes preferentially when located on the recessive subgenome, and with little regard for a gene's level of expression. We hypothesize that small RNA (smRNA)-mediated silencing of transposons near genes causes position-effect down-regulation. Unlike 24-nt smRNA coverage, transposon coverage tracks gene expression, so not all transposons behave identically. We propose that successful ancient tetraploids begin as wide crosses between two lines, each evolved for different tradeoffs between transposon silencing and negative position effects on gene expression. We hypothesize that following a chaotic wide-cross/new tetraploid period, genes acquire their new expression balances based on differences in transposon coverage in the parents. We envision patches of silenceable transposon as quantitative cis-regulators of baseline transcription rate. Attractive solutions to heterosis and the C-value paradox are mentioned.
学科主题	Multidisciplinary Sciences
语种	英语
出版者	NATL ACAD SCIENCES
WOS记录号	WOS:000333985200058
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/101838]
专题	蔬菜花卉研究所
作者单位	1.Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA 2.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China 3.Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA
推荐引用方式 GB/T 7714	Woodhouse, Margaret R.,Cheng, Feng,Pires, J. Chris,et al. Origin, inheritance, and gene regulatory consequences of genome dominance in polyploids[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2014,111(14):5283-5288.
APA	Woodhouse, Margaret R.,Cheng, Feng,Pires, J. Chris,Lisch, Damon,Freeling, Michael,&Wang, Xiaowu.(2014).Origin, inheritance, and gene regulatory consequences of genome dominance in polyploids.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,111(14),5283-5288.
MLA	Woodhouse, Margaret R.,et al."Origin, inheritance, and gene regulatory consequences of genome dominance in polyploids".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111.14(2014):5283-5288.