Synthesis, Bioactivities and Structure Activity Relationship of N-4-Methyl-1,2,3-thiadiazole-5-carbonyl-N&#039;-phenyl Ureas

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	Synthesis, Bioactivities and Structure Activity Relationship of N-4-Methyl-1,2,3-thiadiazole-5-carbonyl-N'-phenyl Ureas
	Guo Dandan 1; Wang Zhiwen 1; Fan Zhijin 1; Zhao Hui 1; Zhang Wei 2; Cheng Jiagao 2; Yang Jiaqiang 3; Wu Qingjun 3; Zhang Youjun 3; Fan Qian 3
刊名	Chinese Journal of Chemistry
	2012
卷号	30 期号:10 页码:2522-2532
关键词	4-methyl-l,2,3-thiadiazole derivatives benzoylurea pesticides insecticidal activity 3D QSAR model
ISSN号	1001-604X
英文摘要	Twenty nine novel N-4-methyl-1,2,3-thiadiazole-5-carbonyl-N'-phenyl ureas were designed and synthesized, and their structures were confirmed by proton nuclear magnetic resonance (~1H NMR), infra red spectroscopy (IR) and high-resolution mass spectroscopy (HRMS). Compounds V-9, V-11, V-12, V-15, V-19, V-21, V-22 and V-24 exhibit excellent activity against Culex pipiens pallens. Compounds V-12 and V-22 present good insecticidal activity against Plutella xylostella L. Their median lethal concentrations (LC_(50)) are 164.15 and 89.69 mg.L~(-1), respectively. Compound V-ll also has potential wide spectrum of fungicide activity. Its median effective concentrations (EC_(50)) detected from 3.82 μg·mL~(-1) against Physalospora piricola to 31.60 μg·mL~(-1) against Cercospora arachidicola. Compounds V-15 and V-24 show outstanding induction activities as same as positive controls TDL and ningnanmycin, furthermore V-24 has the highest induction activity of 41.85% ±4.43%. To elucidate the structure activity relationship in these compounds, a 3D-QSAR model has been built. The established model showed a reliable predicting ability with q~2 values of 0.643 and r~2 values of 0.982.
学科主题	化学
语种	中文
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/100620]
专题	蔬菜花卉研究所
作者单位	1.Nankai University, State Key Laboratory of Elemento-Organic Chemistry, Tianjin, 300071 2.School of Pharmacy, East China University of Science and Technology, Shanghai Key Laboratory of Chemical Biology, Shanghai, 200237 3.Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081
推荐引用方式 GB/T 7714	Guo Dandan,Wang Zhiwen,Fan Zhijin,et al. Synthesis, Bioactivities and Structure Activity Relationship of N-4-Methyl-1,2,3-thiadiazole-5-carbonyl-N'-phenyl Ureas[J]. Chinese Journal of Chemistry,2012,30(10):2522-2532.
APA	Guo Dandan.,Wang Zhiwen.,Fan Zhijin.,Zhao Hui.,Zhang Wei.,...&Fan Qian.(2012).Synthesis, Bioactivities and Structure Activity Relationship of N-4-Methyl-1,2,3-thiadiazole-5-carbonyl-N'-phenyl Ureas.Chinese Journal of Chemistry,30(10),2522-2532.
MLA	Guo Dandan,et al."Synthesis, Bioactivities and Structure Activity Relationship of N-4-Methyl-1,2,3-thiadiazole-5-carbonyl-N'-phenyl Ureas".Chinese Journal of Chemistry 30.10(2012):2522-2532.