Antidepressant Effects of Ginsenosides from Panax notoginseng

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	Antidepressant Effects of Ginsenosides from Panax notoginseng
	Yao Yang; Sang Wei; Yang Xiushi; Zhai Meijing; Wang Lili; Qin Peiyou; Wu Li; Zhou Xianrong; Wang Lijun; Li Jinyan
刊名	Journal of Integrative Agriculture
	2012
卷号	11 期号:3 页码:483-488
关键词	Panax notoginseng saponins forced swimming tail suspension antidepressant-like effect monoamine
ISSN号	2095-3119
英文摘要	Ginsenosides Rg 1,Rb 1,R 1,Rd,and Re are major constituents of Panax notoginseng,a famous traditional Chinese medicinal herb,which has both stimulative and inhibitory effects on the central nervous system (CNS).The monoamine hypothesis proposes that depression is a result of the depletion of 5-hydroxytryptamine (5-HT),norepinephrine (NE) and dopamine (DA) in addition to the activation of monoamine oxidase in the CNS.The purpose of this study was to determine whether P.notoginseng Saponin (PNS) has an antidepressant activity.We investigated the antidepressant-like activities of Rg 1,Rb 1,R 1,Rd,and Re in mice,using two animal models of depression.In addition,we analyzed the neurochemicals by the chronic unpredictable mild stress test.Our results showed that Rb 1,Rd,and Re treatment at 10 mg kg~(-1) significantly reduced the duration of immobility in both the tail suspension and forced swimming tests.Rb 1,Rd,and Re increases in 5HT and NE levels at 10 mg kg~(-1) in both the frontal cortex and hippocampus.Dopamine levels increased in the hippocampus and the striatum.Moreover,5-hydroxyindoleacetic acid (5-HIAA) levels were found increased in the hippocampus.These findings suggest that the antidepressant effects of Rb 1,Rd,and Re may be related to the increase in 5-HT and NE in the CNS,and through the alterations in the synthesis or metabolism of dopamine.
学科主题	农作物
语种	英语
内容类型	期刊论文
源URL	[http://ir.nais.net.cn/handle/2HMLN22E/131163]
专题	作物科学研究所
作者单位	Institute of Crop Sciences,Chinese Academy of Agricultural Sciences, Beijing, 100081
推荐引用方式 GB/T 7714	Yao Yang,Sang Wei,Yang Xiushi,et al. Antidepressant Effects of Ginsenosides from Panax notoginseng[J]. Journal of Integrative Agriculture,2012,11(3):483-488.
APA	Yao Yang.,Sang Wei.,Yang Xiushi.,Zhai Meijing.,Wang Lili.,...&Ren Guixing.(2012).Antidepressant Effects of Ginsenosides from Panax notoginseng.Journal of Integrative Agriculture,11(3),483-488.
MLA	Yao Yang,et al."Antidepressant Effects of Ginsenosides from Panax notoginseng".Journal of Integrative Agriculture 11.3(2012):483-488.