Genome-wide association study of resistance to rough dwarf disease in maize

doi:10.1007/s10658-014-0383-z

	Genome-wide association study of resistance to rough dwarf disease in maize
	Liu, Changlin 1; Weng, Jianfeng 1; Zhang, Degui 1; Zhang, Xiaocong 1; Yang, Xiaoyan 2; Shi, Liyu 1; Meng, Qingchang 3; Yuan, Jianhua 3; Guo, Xinping 4; Hao, Zhuanfang 1
刊名	EUROPEAN JOURNAL OF PLANT PATHOLOGY
	2014
卷号	139 期号:1 页码:205-216
关键词	Maize rough dwarf disease Genome-wide association study Single-nucleotide polymorphism Quantitative trait loci (QTL)
ISSN号	0929-1873
DOI	10.1007/s10658-014-0383-z
通讯作者	Liu, Changlin
英文摘要	Maize rough dwarf disease (MRDD), caused by the Maize rough dwarf virus (MRDV) is highly prevalent across summer at maize-growing areas in China. To investigate the genetic architecture underlying this viral disease, a set of 236 Chinese maize inbred lines was evaluated for resistance to MRDD in 2010 and 2011. Based on 41,101 single-nucleotide polymorphism (SNP) markers with minor allele frequencies (MAF) greater than 5 %, a genome-wide association study (GWAS) was employed to identify genomic loci for resistance to MRDD. A total of 73 SNPs were found to be associated with resistance to MRDD at a significance threshold of -log10 (P) > 4 controlling the false discovery rate (FDR) at alpha = 0.1. Fourteen of these SNPs were detected in both of the two environments tested. A total of 48 SNPs were identified in linkage disequilibrium (LD) blocks containing candidate resistance genes, including protein kinase genes. Using the pedigree information and whole-genome SNP analysis of five highly resistant inbred lines derived from the hybrid 'P78599', nine derivative fragments harbouring SNPs associated with MRDD resistance were detected. One 81.57 Mb fragment in particular located in bin 8.03, which contained six SNPs associated with MRDD resistance, and included the major quantitative trait loci (QTL) that had been identified in the previous study. These results suggest that the SNPs and fragments associated with MRDD resistance, especially those in bin 8.03, could be used for fine mapping of resistance genes and developing resistant varieties in maize.
学科主题	Agronomy ; Plant Sciences ; Horticulture
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000333696500020
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/4892]
专题	作物科学研究所_转基因中心
作者单位	1.Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100081, Peoples R China 2.Chongqing Acad Agr Sci, Chongqing 401329, Peoples R China 3.Jiangsu Acad Agr Sci, Nanjing 210014, Jiangsu, Peoples R China 4.Jining Acad Agr Sci, Jining 272000, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Liu, Changlin,Weng, Jianfeng,Zhang, Degui,et al. Genome-wide association study of resistance to rough dwarf disease in maize[J]. EUROPEAN JOURNAL OF PLANT PATHOLOGY,2014,139(1):205-216.
APA	Liu, Changlin.,Weng, Jianfeng.,Zhang, Degui.,Zhang, Xiaocong.,Yang, Xiaoyan.,...&Zhang, Shihuang.(2014).Genome-wide association study of resistance to rough dwarf disease in maize.EUROPEAN JOURNAL OF PLANT PATHOLOGY,139(1),205-216.
MLA	Liu, Changlin,et al."Genome-wide association study of resistance to rough dwarf disease in maize".EUROPEAN JOURNAL OF PLANT PATHOLOGY 139.1(2014):205-216.