Genome-wide association study dissects the genetic architecture of oil biosynthesis in maize kernels

doi:10.1038/ng.2484

	Genome-wide association study dissects the genetic architecture of oil biosynthesis in maize kernels
	Li, Hui 1; Peng, Zhiyu 2; Yang, Xiaohong 1; Wang, Weidong 1; Fu, Junjie 3; Wang, Jianhua 1; Han, Yingjia 1; Chai, Yuchao 1; Guo, Tingting 1; Yang, Ning 4
刊名	NATURE GENETICS
	2013
卷号	45 期号:1 页码:43-U72
ISSN号	1061-4036
DOI	10.1038/ng.2484
通讯作者	Li, Hui
英文摘要	Maize kernel oil is a valuable source of nutrition. Here we extensively examine the genetic architecture of maize oil biosynthesis in a genome-wide association study using 1.03 million SNPs characterized in 368 maize inbred lines, including 'high-oil' lines. We identified 74 loci significantly associated with kernel oil concentration and fatty acid composition (P < 1.8 x 10(-6)), which we subsequently examined using expression quantitative trait loci (QTL) mapping, linkage mapping and coexpression analysis. More than half of the identified loci localized in mapped QTL intervals, and one-third of the candidate genes were annotated as enzymes in the oil metabolic pathway. The 26 loci associated with oil concentration could explain up to 83% of the phenotypic variation using a simple additive model. Our results provide insights into the genetic basis of oil biosynthesis in maize kernels and may facilitate marker-based breeding for oil quantity and quality.
学科主题	Genetics & Heredity ; GENETICS & HEREDITY
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000312838800011
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/5090]
专题	作物科学研究所_分子生物学系
作者单位	1.China Agr Univ, Natl Maize Improvement Ctr China, Beijing Key Lab Crop Genet Improvement, Beijing 100094, Peoples R China 2.Beijing Genom Inst Shenzhen, Shenzhen, Peoples R China 3.Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100193, Peoples R China 4.Huazhong Agr Univ, Natl Key Lab Crop Genet Improvement, Wuhan, Peoples R China 5.ARS, Corn Host Plant Resistance Res Unit, USDA, Starkville, MS USA
推荐引用方式 GB/T 7714	Li, Hui,Peng, Zhiyu,Yang, Xiaohong,et al. Genome-wide association study dissects the genetic architecture of oil biosynthesis in maize kernels[J]. NATURE GENETICS,2013,45(1):43-U72.
APA	Li, Hui.,Peng, Zhiyu.,Yang, Xiaohong.,Wang, Weidong.,Fu, Junjie.,...&Yan, Jianbing.(2013).Genome-wide association study dissects the genetic architecture of oil biosynthesis in maize kernels.NATURE GENETICS,45(1),43-U72.
MLA	Li, Hui,et al."Genome-wide association study dissects the genetic architecture of oil biosynthesis in maize kernels".NATURE GENETICS 45.1(2013):43-U72.