The SnRK2-APC/C-TE regulatory module mediates the antagonistic action of gibberellic acid and abscisic acid pathways

doi:10.1038/ncomms8981

	The SnRK2-APC/C-TE regulatory module mediates the antagonistic action of gibberellic acid and abscisic acid pathways
	Lin, Qibing 1; Wu, Fuqing 1; Sheng, Peike 1; Zhang, Zhe 1; Zhang, Xin 1; Guo, Xiuping 1; Wang, Jiulin 1; Cheng, Zhijun 1; Wang, Jie 1; Wang, Haiyang 1
刊名	NATURE COMMUNICATIONS
	2015
卷号	6 页码:-
ISSN号	2041-1723
DOI	10.1038/ncomms8981
通讯作者	Lin, Qibing
英文摘要	Abscisic acid (ABA) and gibberellic acid (GA) antagonistically regulate many developmental processes and responses to biotic or abiotic stresses in higher plants. However, the molecular mechanism underlying this antagonism is still poorly understood. Here, we show that loss-of-function mutation in rice Tiller Enhancer (TE), an activator of the APC/C-TE complex, causes hypersensitivity and hyposensitivity to ABA and GA, respectively. We find that TE physically interacts with ABA receptor OsPYL/RCARs and promotes their degradation by the proteasome. Genetic analysis also shows OsPYL/RCARs act downstream of TE in mediating ABA responses. Conversely, ABA inhibits APC/C-TE activity by phosphorylating TE through activating the SNF1-related protein kinases (SnRK2s), which may interrupt the interaction between TE and OsPYL/RCARs and subsequently stabilize OsPYL/RCARs. In contrast, GA can reduce the level of SnRK2s and may promote APC/CTE-mediated degradation of OsPYL/RCARs. Thus, we propose that the SnRK2-APC/C-TE regulatory module represents a regulatory hub underlying the antagonistic action of GA and ABA in plants.
学科主题	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000360346900022
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/4686]
专题	作物科学研究所_分子生物学系
作者单位	1.Chinese Acad Agr Sci, Inst Crop Sci, Natl Key Facil Crop Gene Resources & Genet Improv, Beijing 100081, Peoples R China 2.Nanjing Agr Univ, Jiangsu Plant Gene Engn Res Ctr, Natl Key Lab Crop Genet & Germplasm Enhancement, Nanjing 210095, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Lin, Qibing,Wu, Fuqing,Sheng, Peike,et al. The SnRK2-APC/C-TE regulatory module mediates the antagonistic action of gibberellic acid and abscisic acid pathways[J]. NATURE COMMUNICATIONS,2015,6:-.
APA	Lin, Qibing.,Wu, Fuqing.,Sheng, Peike.,Zhang, Zhe.,Zhang, Xin.,...&Wan, Jianmin.(2015).The SnRK2-APC/C-TE regulatory module mediates the antagonistic action of gibberellic acid and abscisic acid pathways.NATURE COMMUNICATIONS,6,-.
MLA	Lin, Qibing,et al."The SnRK2-APC/C-TE regulatory module mediates the antagonistic action of gibberellic acid and abscisic acid pathways".NATURE COMMUNICATIONS 6(2015):-.