THE PROTECTIVE EFFECTS OF CASSAVA (MANIHOT ESCULENTA CRANTZ) LEAF FLAVONOID EXTRACTS ON LIVER DAMAGE OF CARBON TETRACHLORIDE INJURED MICE

doi:10.4314/ajtcam.v12i1.8

CORC > 中国农业科学院 > 作物科学研究所

	THE PROTECTIVE EFFECTS OF CASSAVA (MANIHOT ESCULENTA CRANTZ) LEAF FLAVONOID EXTRACTS ON LIVER DAMAGE OF CARBON TETRACHLORIDE INJURED MICE
	Tao, Hai-Teng 1; Qiu, Bin 1; Du, Fang-Ling 1; Xu, Tong-Cheng 1; Liu, Li-Na 1; Lu, Feijie 2; Li, Kai-Mian 3; Liu, Wei 1
刊名	AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES
	2015
卷号	12 期号:1 页码:52-56
关键词	Cassava leaf flavonoid Carbon tetrachloride Liver injury Protective effects
ISSN号	0189-6016
DOI	10.4314/ajtcam.v12i1.8
通讯作者	Tao, Hai-Teng
英文摘要	Background: Cassava leaf contains many kinds of flavonoids, most of flavonoids function as effective antioxidants in vivo. The protective effects of cassava (Manihot esculenta Crantz) leaf flavonoid extracts on liver damage were evaluated by carbon tetrachloride (CCl4)-induced injury in mice.Materials and methods: The protective effects of cassava leaf flavonoid extracts on liver damage were evaluated using CCl4-induced injury in mice. The mice were weighted to calculate sample quantity of mice. Bloods were taken to evaluate ALT and AST of serums. Livers were excised and weighted, and fixed for pathological observation. Prepared 10% liver tissue homogenate was used to evaluate MDA, SOD, GSH-PX levels.Results: Cassava leaf flavonoid extracts significantly decreased (p < 0.05) the relative liver weight when compared with the CCl4-treated group. The contents of ALT and AST in serum of experiment mice declined significantly when compared to those of the CCl4-treated group, but did not reach normal levels of control group. Pathological observation of livers showed that cassava leaf flavonoid extracts significantly ameliorated the CCl4-induced pathological changes.Conclusion These results provided biological evidence that cassava leaf flavonoid extracts indeed expressed potential efficacy of prohibiting liver injury in mice.
学科主题	Integrative & Complementary Medicine
语种	英语
出版者	AFRICAN NETWORKS ETHNOMEDICINES
WOS记录号	WOS:000350409700008
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/4780]
专题	作物科学研究所
作者单位	1.Shandong Acad Agr Sci, Inst Agro Food Sci & Technol, Jinan 250100, Peoples R China 2.Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100081, Peoples R China 3.Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Inst, Danzhou 571737, Hainan, Peoples R China
推荐引用方式 GB/T 7714	Tao, Hai-Teng,Qiu, Bin,Du, Fang-Ling,et al. THE PROTECTIVE EFFECTS OF CASSAVA (MANIHOT ESCULENTA CRANTZ) LEAF FLAVONOID EXTRACTS ON LIVER DAMAGE OF CARBON TETRACHLORIDE INJURED MICE[J]. AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES,2015,12(1):52-56.
APA	Tao, Hai-Teng.,Qiu, Bin.,Du, Fang-Ling.,Xu, Tong-Cheng.,Liu, Li-Na.,...&Liu, Wei.(2015).THE PROTECTIVE EFFECTS OF CASSAVA (MANIHOT ESCULENTA CRANTZ) LEAF FLAVONOID EXTRACTS ON LIVER DAMAGE OF CARBON TETRACHLORIDE INJURED MICE.AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES,12(1),52-56.
MLA	Tao, Hai-Teng,et al."THE PROTECTIVE EFFECTS OF CASSAVA (MANIHOT ESCULENTA CRANTZ) LEAF FLAVONOID EXTRACTS ON LIVER DAMAGE OF CARBON TETRACHLORIDE INJURED MICE".AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES 12.1(2015):52-56.