Robustness and Coherence of a Three-Protein Circadian Oscillator: Landscape and Flux Perspectives

	Robustness and Coherence of a Three-Protein Circadian Oscillator: Landscape and Flux Perspectives
	Wang J ; Xu L ; Wang E
刊名	biophysical journal
	2009
卷号	97 期号:11 页码:3038-3046
关键词	MAPK SIGNAL-TRANSDUCTION GENE-EXPRESSION KAIC PHOSPHORYLATION CELLULAR NETWORKS ENERGY LANDSCAPE DISSIPATION COST INTRINSIC NOISE MOLECULAR NOISE CLOCK CYANOBACTERIA
ISSN号	0006-3495
通讯作者	wang j
中文摘要	three-protein circadian oscillations in cyanobacteria sustain for weeks. to understand how cellular oscillations function robustly in stochastic fluctuating environments, we used a stochastic model to uncover two natures of circadian oscillation: the potential landscape related to steady-state probability distribution of protein concentrations; and the corresponding flux related to speed of concentration changes which drive the oscillations. the barrier height of escaping from the oscillation attractor on the landscape provides a quantitative measure of the robustness and coherence for oscillations against intrinsic and external fluctuations. the difference between the locations of the zero total driving force and the extremal of the potential provides a possible experimental probe and quantification of the force from curl flux. these results, correlated with experiments, can help in the design of robust oscillatory networks.
收录类别	SCI
语种	英语
WOS记录号	WOS:000272274500022
公开日期	2010-05-27
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/12201]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wang J,Xu L,Wang E. Robustness and Coherence of a Three-Protein Circadian Oscillator: Landscape and Flux Perspectives[J]. biophysical journal,2009,97(11):3038-3046.
APA	Wang J,Xu L,&Wang E.(2009).Robustness and Coherence of a Three-Protein Circadian Oscillator: Landscape and Flux Perspectives.biophysical journal,97(11),3038-3046.
MLA	Wang J,et al."Robustness and Coherence of a Three-Protein Circadian Oscillator: Landscape and Flux Perspectives".biophysical journal 97.11(2009):3038-3046.