Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis
	Dai, Zhi 1,3; Li, Shi-Rong 1,3; Zhu, Pei-Feng 2,3; Liu, Lu 2,3; Wang, Bei 2,3; Liu, Ya-Ping 2; Luo, Xiao-Dong2 ; Zhao, Xu-Dong 1
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2017-07-01
卷号	27 页码:2863-2867
关键词	Isocostunolide Glioma stem cells Cell proliferation Apoptosis Colony formation
英文摘要	Glioblastoma multiform (GBM) is a highly aggressive brain tumor with poor life expectancy, and glioma stem cells (GSCs) are a small population of tumor cells existed in GBM, in which GSCs response to drive GBM recurrence, invasion and contribute to the anti-cancer resistance. GSCs have been identified and developed as a therapeutic target for GBM and can be used in drugs screening. Isocostunolide is a natural sesquiterpenoid and contained abundant resource in medicinal plants, but the anti-cancer efficacies of it against GSCs are still unexplored. In this investigation, the anti-tumor activity of isocostunolide against GSCs was investigated and the result demonstrated that it inhibited the growth of GSCs (GSC-3#, GSC-12#, GSC-18#) significantly with an IC50 value of 2.80 mu g/ml, 2.61 mu g/ml, 1.07 mu g/ml, respectively. In further mechanism study, isocostunolide inhibited GSCs cell proliferation, induced GSCs apoptosis significantly, as well as increased the proportion of the cleavage of caspase-3. The result suggested that isocostunolide induced GSCs apoptosis via the caspase dependent apoptotic pathway. Moreover, isocostunolide damaged GSCs colony formation capacity significantly and exhibited the anti-cancer efficacy against GSCs in vitro. (C) 2017 Published by Elsevier Ltd.
类目[WOS]	Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]	Pharmacology & Pharmacy ; Chemistry
关键词[WOS]	CENTRAL-NERVOUS-SYSTEM ; BRAIN-TUMORS ; GLIOBLASTOMA ; IDENTIFICATION ; TEMOZOLOMIDE ; RESISTANCE
收录类别	SCI
语种	英语
WOS记录号	WOS:000402470600005
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/51348]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Bioact Peptides Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, 21 QingSong Rd, Kunming 650223, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 LanHei Rd, Kunming 650201, Yunnan Province, Peoples R China 3.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Dai, Zhi,Li, Shi-Rong,Zhu, Pei-Feng,et al. Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27:2863-2867.
APA	Dai, Zhi.,Li, Shi-Rong.,Zhu, Pei-Feng.,Liu, Lu.,Wang, Bei.,...&Zhao, Xu-Dong.(2017).Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27,2863-2867.
MLA	Dai, Zhi,et al."Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27(2017):2863-2867.