Chrodrimanins K-N and Related Meroterpenoids from the Fungus Penicillium sp. SCS-KFD09 Isolated from a Marine Worm, Sipunculus nudus

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Chrodrimanins K-N and Related Meroterpenoids from the Fungus Penicillium sp. SCS-KFD09 Isolated from a Marine Worm, Sipunculus nudus
	Kong, FD; Ma, QY; Huang, SZ; Wang, P; Wang, JF; Zhou, LM; Yuan, JZ; Dai, HF; Zhao, YX
刊名	JOURNAL OF NATURAL PRODUCTS
	2017
卷号	80 期号:4 页码:1039-1047
通讯作者	daihaofu@itbb.org.cn ; zhaoyouxing@itbb.org.cn
中文摘要	Six new meroterpenoids, chrodrimanins K-N (1-4), including two uncommon chlorinated one (1 and 2), and verruculides B2 (5) and B3 (6), as well as seven known ones (7-13), were isolated from the fermentation broth of Penitillinm sp. SCS-KFD09, isolated from a marine worm, Sipunculus nuchis, from Haikou Bay, China., The, structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic data, X-ray diffraction analysis, and ECD spectra analysis along with quantum ECD calculations. In addition, the X-ray crystal structures and, absolute configurations :of two previously reported tneroterpenoids, chrodrimanins F (9) and A (11), are described for the first time. Compounds 1, 4, and 7 displayed anti-H1N1 activity with IC50 values of-74,, 58, and 34 mu M, respectively, while compound 5 showed, weak inhibitory activity against Staphylococcus atireas with an MIC of 32 mu g/mL.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/16260]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Kong, FD,Ma, QY,Huang, SZ,et al. Chrodrimanins K-N and Related Meroterpenoids from the Fungus Penicillium sp. SCS-KFD09 Isolated from a Marine Worm, Sipunculus nudus[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(4):1039-1047.
APA	Kong, FD.,Ma, QY.,Huang, SZ.,Wang, P.,Wang, JF.,...&Zhao, YX.(2017).Chrodrimanins K-N and Related Meroterpenoids from the Fungus Penicillium sp. SCS-KFD09 Isolated from a Marine Worm, Sipunculus nudus.JOURNAL OF NATURAL PRODUCTS,80(4),1039-1047.
MLA	Kong, FD,et al."Chrodrimanins K-N and Related Meroterpenoids from the Fungus Penicillium sp. SCS-KFD09 Isolated from a Marine Worm, Sipunculus nudus".JOURNAL OF NATURAL PRODUCTS 80.4(2017):1039-1047.