Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp ZSDS1-F7

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	Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp ZSDS1-F7
	He, WJ; Zhou, XJ; Qin, XC; Mai, YX; Lin, XP; Liao, SR; Yang, B; Zhang, TY; Tu, ZC; Wang, JF
刊名	NATURAL PRODUCT RESEARCH
	2017
卷号	31 期号:5 页码:604-609
关键词	Sponge-derived fungus Phakellia fusca Thiele meroterpenoid roquefortine cytotoxic activity antitubercular activity anti-enterovirus 71 activity
通讯作者	wangjunfeng@scsio.ac.cn ; yonghongliu@scsio.ac.cn
中文摘要	Fifteen compounds, including six quinone/hydroquinone meroter-penoids, purpurogemutantin (1), macrophorin A (2), 4'-oxomacrophorin (3), 7-deacetoxyyanuthone A (4), 2,3-hydro-deacetoxyyanuthone A (5), 22-deacetylyanuthone A (6), anicequol (7), three roquefortine derivatives, roquefortine C (8), (16S)-hydroxyroquefortine C (9), (16R)-hydroxyroquefortine C (10), dihydroresorcylide (11), nectriapyrone (12), together with three fatty acid derivatives, methyl linoleate (13), phospholipase A 2 (14), methyl elaidate (15), were isolated from the sponge-derived fungus Gliomastix sp. ZSDS1-F7 isolated from the sponge Phakellia fusca Thiele collected in the Yongxing island of Xisha. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analyses. Among these compounds, compounds 1-3 and 5-7 showed significant in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4 and HL60 cell lines, with IC50 values ranging from 0.19 to 35.4 mu M. And compounds 2-4 exhibited antitubercular activity with IC 50 values of 22.1, 2.44 and 17.5 mu M, respectively. Furthermore, compound 7 had anti-enterovirus 71 activity with MIC value of 17.8 mu M. To the best of our knowledge, this is the first report to product two quinone/hydroquinone meroterpenoids skeletons (linear skeleton and drimane skeleton) from the same fungal strain. [GRAPHICS] .
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/16213]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	He, WJ,Zhou, XJ,Qin, XC,et al. Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp ZSDS1-F7[J]. NATURAL PRODUCT RESEARCH,2017,31(5):604-609.
APA	He, WJ.,Zhou, XJ.,Qin, XC.,Mai, YX.,Lin, XP.,...&Liu, YH.(2017).Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp ZSDS1-F7.NATURAL PRODUCT RESEARCH,31(5),604-609.
MLA	He, WJ,et al."Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp ZSDS1-F7".NATURAL PRODUCT RESEARCH 31.5(2017):604-609.