Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism.

CORC > 上海有机化学研究所 > 中国科学院上海有机化学研究所 > 生命有机化学国家重点实验室

	Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism.
	Wu YL(吴毓林) ; Chen HB(陈海宝) ; Jiang K(蒋昆) ; Li Y(李英) ; Shan F(山峰) ; Wang DY(王东业) ; Wang YF(王燕芳) ; Wu WM(吴文敏) ; Wu YK(伍贻康) ; Yao ZJ(姚祝军) ; Le ZY(乐征宇) ; Zhou CM(周澄明)
刊名	Pure Appl. Chem.
	1999
卷号	71 期号:6 页码:1139-1142
ISSN号	0033-4545
其他题名	亚铁离存在下青蒿素及其衍生物分子的作用－抗疟机制探讨
通讯作者	吴毓林
英文摘要	Qinghaosu(artemisinin) is the antimalarial principle of the Chinese traditional herb qinghao (Artemisia annua L.). Now qinghaosu and its derivatives have distinguished themselaves as a new generation of antimalarial drugs, especially in the treatment of multidrug-resistant cases. Qinghaosu has a unique carbon framework containing a special endoperoxy dridge, which is entirely different from that of all previous antimalarial agents and hence makes a novel antimalarial mechanism possible. Up to now there is still no clear picture about this mechanism at the molecular lever. However, the ferric/ferrous ions that are abundant in the red cell in which the parasite lives, is likely the most important co-factor for the antimalarial process of qinghaosu (scheme 1).
学科主题	有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1351/pac199971061139
语种	英语
公开日期	2013-01-17
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/13946]
专题	上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Wu YL,Chen HB,Jiang K,et al. Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism.[J]. Pure Appl. Chem.,1999,71(6):1139-1142.
APA	吴毓林.,陈海宝.,蒋昆.,李英.,山峰.,...&周澄明.(1999).Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism..Pure Appl. Chem.,71(6),1139-1142.
MLA	吴毓林,et al."Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism.".Pure Appl. Chem. 71.6(1999):1139-1142.