BmTx3B, a novel scorpion toxin from buthus martensi karsch, inhibits delayed rectifier potassium current in rat hippocampal neurons

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	BmTx3B, a novel scorpion toxin from buthus martensi karsch, inhibits delayed rectifier potassium current in rat hippocampal neurons
	Li MH(李明华) ; Wang YF(王跃丰) ; Chen XQ(陈雪琴) ; Zhang NX(张乃霞) ; Wu HM(吴厚铭) ; Hu GY(胡国渊)
刊名	Acta Pharmacol. Sin.
	2003
卷号	24 期号:10 页码:1016-1020
ISSN号	1671-4083
其他题名	BmTx3B, 马氏钳蝎毒液中的一个新颖毒素，抑制海马神经元的加电流
通讯作者	胡国渊
英文摘要	To examine the effect of BmTx3B, a novel shon-chain peptide isolated from the venom of Asian scorpion Buthus Hlartensi Karsch, on voltage-gated potassium channels. METHODS: Two types of voltage-dependent potassium currents were recorded from dissociated hippocampal neurons of neonatal rat in whole-cell voltage-clamp mode, and separated based upon their kinetic propeHies. RESULTS: BmTx3B (1O-IOO pmol/L) selectively inhibited the delayed rectifier potassium current (IK), without affecting the fast transient potassium cunent (IA). The inhibition of the peptide on IK was reversible, concentration-dependent and voltage-independent. BmTx3B did not affect the steady-state activation and inactivation kinetics of the current. CONCLUSION: The shoH-chain scorpion peptide BmTx3B selectively blocked the delayed rectifier potassium channel.
学科主题	生命有机化学
收录类别	SCI
语种	英语
WOS记录号	WOS:000185749400011
公开日期	2013-02-21
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/17325]
专题	上海有机化学研究所_上海有机化学研究所
推荐引用方式 GB/T 7714	Li MH,Wang YF,Chen XQ,et al. BmTx3B, a novel scorpion toxin from buthus martensi karsch, inhibits delayed rectifier potassium current in rat hippocampal neurons[J]. Acta Pharmacol. Sin.,2003,24(10):1016-1020.
APA	李明华,王跃丰,陈雪琴,张乃霞,吴厚铭,&胡国渊.(2003).BmTx3B, a novel scorpion toxin from buthus martensi karsch, inhibits delayed rectifier potassium current in rat hippocampal neurons.Acta Pharmacol. Sin.,24(10),1016-1020.
MLA	李明华,et al."BmTx3B, a novel scorpion toxin from buthus martensi karsch, inhibits delayed rectifier potassium current in rat hippocampal neurons".Acta Pharmacol. Sin. 24.10(2003):1016-1020.