Study on the deformations of the lamina cribrosa during glaucoma

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	Study on the deformations of the lamina cribrosa during glaucoma
	Tian HJ(田晗菁); Li L(李龙); Song F(宋凡)
刊名	ACTA BIOMATERIALIA
	2017-06-01
卷号	55 页码:340-348
关键词	Lamina cribrosa Glaucoma Deformation Optic nerve injury Reissner's thin plate theory
ISSN号	1742-7061
中文摘要	The lamina cribrosa is the primary site of optic nerve injury during glaucoma and its deformations induced by elevated intraocular pressure are associated directly with the optic nerve injury and visual field defect. However the deformations in a living body have been poorly understood yet so far. It is because that integral observation and precise measurement of the deformations in vivo are now almost impossible in the clinical diagnosis and treatment of glaucoma. In the present study a new mechanical model of the lamina cribrosa is presented by using Reissner's thin plate theory. This model accurately displays the stress and deformation states in the lamina cribrosa under elevated intraocular pressure in which the shear deformation is not presented by the previous models however is demonstrated to play a key role in the optic nerve injury. Further the deformations of the structures involving the optic nerve channels and the laminar sheets in the lamina cribrosa are first investigated in detail. For example the dislocation of the laminar sheets reaches 18.6 mu m under the intraocular pressure of 40 mmHg which is large enough to damage the optic nerve axons. The results here confirm some previously proposed clinical speculations on the deformations of the pore shape in the lamina cribrosa under elevated intraocular pressure during glaucoma. Finally some essentially clinical questions existed during glaucoma such as the pathological mechanism of the open-angle glaucoma with normal intraocular pressure are discussed. The present study is beneficial to deeply understanding the optic nerve injury during glaucoma.
类目[WOS]	Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]	Engineering ; Materials Science
关键词[WOS]	OPTIC-NERVE HEAD ; INTRAOCULAR-PRESSURE ELEVATION ; OPEN-ANGLE GLAUCOMA ; MATHEMATICAL-MODEL ; HUMAN EYES ; BIOMECHANICS ; DAMAGE ; DISEASE ; DISC
收录类别	SCI
语种	英语
WOS记录号	WOS:000403414500026
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/60512]
专题	力学研究所_非线性力学国家重点实验室
推荐引用方式 GB/T 7714	Tian HJ,Li L,Song F. Study on the deformations of the lamina cribrosa during glaucoma[J]. ACTA BIOMATERIALIA,2017,55:340-348.
APA	田晗菁,李龙,&宋凡.(2017).Study on the deformations of the lamina cribrosa during glaucoma.ACTA BIOMATERIALIA,55,340-348.
MLA	田晗菁,et al."Study on the deformations of the lamina cribrosa during glaucoma".ACTA BIOMATERIALIA 55(2017):340-348.