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	Production of paclitaxel loaded PLA-lecithin ultrasound contrast agents
	Yang, Xiang Rui ; Wu, Shi Chao ; Hou, Zheng Qing ; Wang, Yan Ge ; Jiang, Qian ; Hou ZQ(侯振清) ; Wang YG(王衍戈)
	2013
关键词	Diagnosis Emulsification Encapsulation Ultrasonic imaging Ultrasonics
英文摘要	Conference Name:2013 International Conference on Bio-Medical Materials and Engineering, ICBME 2013. Conference Address: Hong Kong, China. Time:March 26, 2013 - March 27, 2013.; Drug loaded PLA (or PLGA) mirobubbles that combine properties of ultrasound imaging contrast agents and drug carriers suffer from low encapsulation efficiency and difficulty to destruction with diagnosis ultrasound. In this paper, a new type of multifunctional paclitaxel-loaded poly lactide-lecithin(PLA-lecithin)microbubbles has been developed with a method of ultrasonic double emulsion solvent evaporation (UDES) combined with lyophilization, and single-factor of ultrasonic time was studied to influence bubble size and drug loading efficiency. Bubbles were characterized to be well dispersed, with size of 300nm~2um, and showed increased ultrasound imaging on rabbit liver and heart after intravenous injection. ? (2013) Trans Tech Publications, Switzerland.
语种	英语
出处	http://dx.doi.org/10.4028/www.scientific.net/AMR.749.318
出版者	Trans Tech Publications Ltd
内容类型	其他
源URL	[http://dspace.xmu.edu.cn/handle/2288/85116]
专题	材料学院－会议论文
推荐引用方式 GB/T 7714	Yang, Xiang Rui,Wu, Shi Chao,Hou, Zheng Qing,et al. Production of paclitaxel loaded PLA-lecithin ultrasound contrast agents. 2013-01-01.

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