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	Development of planar microelectrode array for extracellular characterization of action potentials in sinoatrial node cells
	Zhang, ; Zhang, Yulong ; Li, Yingxin ; Nelson, Richard D. ; LaRue, John C. ; Zhang YL(张玉龙)
	2011
关键词	Bioinformatics Biosensors Cells Characterization Chemical compounds Electrophysiology Microchannels Photoresists Silica Silicon nitride
英文摘要	Conference Name:2nd International Symposium on Bioelectronics and Bioinformatics, ISBB 2011. Conference Address: Suzhou, China. Time:November 3, 2011 - November 5, 2011.; In this research work we prototyped a planar microelectrode arrays that utilize SU-8 as the insulating material for non-invasive chronically characterization of action potentials from SA node cells. The microelectrode arrays are fabricated to form a microchannel based extracellular action potential characterization system which comprises a 2 by 50 linear microelectrode array for acquiring the action potentials with the principle of capacitive coupling and a full customized CMOS analog bio-signal readout ASIC for bio-signal conditioning and processing. The prototyped multi-channel mixed signal fully-customized CMOS biosensor analog front-end serves as the low magnitude action potential signal readout circuitry, which is comprised of analog signal buffers, high gain amplifier and control/interface. The concept of using epoxy-based photoresist SU-8 as the insulator instead of the conventional silicon nitride or silicon dioxide is due to the high insulation property and bio-compatibility of the SU-8 material. This biocompatible planar microelectrode arrays with microchannels provides the biological scientists powerful tools for the long term non-invasive study of action potentials from SA node cells to screen libraries of chemical compounds for new drug candidates. ? 2011 IEEE.
语种	英语
出处	http://dx.doi.org/10.1109/ISBB.2011.6107630
出版者	IEEE Computer Society
内容类型	其他
源URL	[http://dspace.xmu.edu.cn/handle/2288/86361]
专题	物理技术－会议论文
推荐引用方式 GB/T 7714	Zhang,,Zhang, Yulong,Li, Yingxin,et al. Development of planar microelectrode array for extracellular characterization of action potentials in sinoatrial node cells. 2011-01-01.

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