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题名僧帽牡蛎低分子活性肽组分BPO-L对人肺腺癌A549细胞的诱导分化作用研究; Studies of the differentiation effect induced by BPO-L on the human lung adenocarcinoma A549 cells
作者黄大川
答辩日期2002 ; 2002
导师李祺福
关键词牡蛎低分子活性肽 人肺腺癌A549细胞 诱导分化 Oyster BPO-L lung cancer cells induced differentiation
英文摘要从僧帽牡蛎中分离提取的低分子活性肽BPO-L处理人肺腺癌A549细胞,以HMBA和姜黄素为平行对照,观察鉴定牡蛎低分子活性肽对人肺腺癌细胞的生物学效应及其作用性质,并进一步探索牡蛎低分子活性肽对人肺腺癌细胞的作用机制。 实验结果表明,0.1mg/mLBPO-L能有效抑制人肺腺癌A549细胞增殖活动,细胞生长抑制率为39.5%,分裂指数抑制率为28.95%,细胞周期发生明显阻滞,G0/G1细胞比例增加,S期细胞比例下降。光镜、透射电镜的观察结果显示,经BPO-L、HMBA及其组合处理后的A549细胞趋于扁平铺展状态,细胞体积增大,核质比例减小,核形状较为规则,核内异染色质减少,常染色质增多,高...; In this study, we used BPO-L, together with a HMBA, cureumin as control and their combination to treat the human adenocarinoma A549 cells for investigating the biological effects and them antiumor mechanisms of BPO-L by the methods of biochemistry, cell biology and immune biology. The results revealed that the proliferation of A549 were effectively inhibited after being treated with 0.1mg/mL BPO-...; 学位:理学硕士; 院系专业:生命科学学院生物学系_细胞生物学; 学号:199926026
语种zh_CN
出处http://210.34.4.13:8080/lunwen/detail.asp?serial=2417
内容类型学位论文
源URL[http://dspace.xmu.edu.cn/handle/2288/47328]  
专题生命科学-学位论文
推荐引用方式
GB/T 7714
黄大川. 僧帽牡蛎低分子活性肽组分BPO-L对人肺腺癌A549细胞的诱导分化作用研究, Studies of the differentiation effect induced by BPO-L on the human lung adenocarcinoma A549 cells[D]. 2002, 2002.
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