| 维生素B4片溶出度方法学研究; Study on dissolution method of Vitamin B4 tablets | |
| 林燕琼 ; 李彩霞 ; 林惠武 | |
| 2015-06-28 | |
| 关键词 | 维生素B4片 溶出度 紫外分光光度法 Vitamin B4 tablets dissolution UV spectrophotometry |
| 英文摘要 | 目的建立维生素b4片溶出度检测方法。方法采用桨法,以900 M l P H6.8磷酸盐缓冲溶液为溶出介质,温度37.0℃,转速为50 r/MIn,选取时间为45 MIn,经0.45μM微孔滤膜过滤,取续滤液,采用紫外分光光度法测定维生素b4片的溶出量,检测波长为262 nM,溶出限度为标示量的80%。结果维生素b4浓度在4~16μg/M l范围内与吸光度呈良好的线性关系,r=0.9999(n=5),平均回收率为100.1%,rSd=1.0%(n=9)。结论该方法简便、灵敏、准确,对不同生产企业的处方、工艺有一定考察作用,可用于维生素b4片的溶出度测定。; Objective To establish a test method for determining the vitamin B4 tablets dissolution.Methods Paddle method was used to 900 m L p H6.8 phosphate buffer solution as the dissolution medium,the temperature of 37 ℃,the speed of 50 r/min,take time for 45 min.Taking the filtrate through the 0.45 μm microporous membrane filtration,vitamin B4 tablets dissolution quantity determined by ultraviolet spectrophotometry,determined the wavelength of 262 nm,dissolution limit for 80% of the labeled amount.Results Vitamin B4 concentration had a good linear relationship with the absorbance in 4 ~ 16 μg/m L,r = 0.9999( n = 5),the average recovery was 100.1%,RSD = 1.0%( n = 9).Conclusion The method is simple,sensitive and accurate,has certain effect on prescription and study of the process of different production enterprises,can be used for the dissolution determination of vitamin B4 tablets. |
| 语种 | zh_CN |
| 内容类型 | 期刊论文 |
| 源URL | [http://dspace.xmu.edu.cn/handle/2288/123599]  |
| 专题 | 药学院－已发表论文 |
| 推荐引用方式 GB/T 7714 | 林燕琼,李彩霞,林惠武. 维生素B4片溶出度方法学研究, Study on dissolution method of Vitamin B4 tablets[J],2015. |
| APA | 林燕琼,李彩霞,&林惠武.(2015).维生素B4片溶出度方法学研究.. |
| MLA | 林燕琼,et al."维生素B4片溶出度方法学研究".(2015). |
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