The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation

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	The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation
	Huang, X. M. ; Chen, Y. M. ; Li, W. B. ; Cohen, S. N. ; Liao, F. F. ; Li, L. M. ; Xu, H. X. ; Zhang, Y. W. ; Zhang YW(张云武)
刊名	http://dx.doi.org/10.1093/hmg/ddq302
	2010-10
关键词	HUMAN GENOME DISEASE SECRETASE SEQUENCE GENERATION HOMOLOG PEPTIDE NEURONS DNA
英文摘要	National Institutes of Health [R01 NS046673, R01 AG030197, R01 AG021173, R01 NS054880]; Alzheimer's Association; American Health Assistance Foundation; National Natural Science Foundation of China [30973150]; National ST Major Project [2009ZX09103-731]; 9; Retroposition is an important mechanism for gene origination. However, studies to elucidate the functions of new genes originated through retroposition, especially the functions related to diseases, are limited. We recently identified a mouse gene, Rps23 retroposed gene 1 (Rps23rg1), that regulates beta-amyloid (A beta) level and tau phosphorylation, two major pathological hallmarks of Alzheimer's disease (AD), and found that Rps23rg1 originated through retroposition of the mouse ribosomal protein S23 (Rps23) mRNA. Here we show that retroposition of Rps23 mRNA occurred multiple times in different species but only generated another functionally expressed Rps23rg1-homologous gene, Rps23rg2, in mice, whereas humans may not possess functional Rps23rg homologs. Both Rps23rg1 and Rps23rg2 are reversely transcribed relative to the parental Rps23 gene, expressed in various tissues and encode proteins that interact with adenylate cyclases. Similar to the RPS23RG1 protein, RPS23RG2 can upregulate protein kinase A activity to reduce the activity of glycogen synthase kinase-3, A beta level and tau phosphorylation. However, the effects of RPS23RG2 are weaker than those of RPS23RG1 and such a difference could be attributed to the extra carboxyl-terminal region of RPS23RG2, which may have an inhibitory effect. In addition, we show that the transmembrane domain of RPS23RG1 is important for its function. Together, our results present a new gene family, whose products and associated signaling pathways might prevent mice from developing AD-like pathologies.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/66028]
专题	生物医学－已发表论文
推荐引用方式 GB/T 7714	Huang, X. M.,Chen, Y. M.,Li, W. B.,et al. The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation[J]. http://dx.doi.org/10.1093/hmg/ddq302,2010.
APA	Huang, X. M..,Chen, Y. M..,Li, W. B..,Cohen, S. N..,Liao, F. F..,...&张云武.(2010).The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation.http://dx.doi.org/10.1093/hmg/ddq302.
MLA	Huang, X. M.,et al."The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation".http://dx.doi.org/10.1093/hmg/ddq302 (2010).