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	Immunological advantage on small bowel graft induced by simultaneously transplanted liver in porcine auxiliary liver/small bowel transplantation
	Yin, Z. ; Wang, X. ; Li, N. ; Ni, X. ; Jiang, F. ; Li, Y. ; Li, J. ; Li N(李娜)
	2006-12
英文摘要	Conference Name:1st World Transplant Congress (WTC 2006). Conference Address: Boston, MA. Time:JUL 23-27, 2006.; Background. We developed a new porcine model for auxiliary liver/small bowel transplantation (LSBT). The possible immunological advantage on small bowel graft induced by simultaneously transplanted liver in the large animal was assessed. Methods. Thirty outbreed long-white pigs were randomized into two groups. Group A animals received LSBT without immunosuppressive treatment (n = 10). Group B animals had segmental small bowel allotransplantation without immunosuppressive treatment (n 10). The postoperative survival time, initial acute rejection time, and pathological rejection scores were analyzed. Results. There was no remarkable difference in survival time between groups A and B (10.33 days vs 12.89 days, P > .05), but the initial time of acute rejection in intestinal grafts in group A was obviously delayed when compared to group B (8.22 days vs 4.33 days, P < .05), and the rejection scores in group A were remarkably lower than those of group B (0 vs 0.44 on postoperative day (POD) 3, P < .05; 0.22 vs 1.78 on POD 5, P < .05; 1.11 vs 2.56 on POD 7, P < .05). Conclusions. An immunological advantage on intestinal graft can be induced by simultaneously transplanted liver in auxiliary LSBT. Compared to isolated segmental small bowel allotransplantation, the intestinal graft in LSBT has a delayed initial time of acute rejection and lower acute rejection scores. The liver graft may reduce the risk of intestinal rejection and thus protect the bowel graft.
语种	英语
出处	http://dx.doi.org/10.1016/j.transproceed.2006.10.100
出版者	TRANSPLANT P
内容类型	其他
源URL	[http://dspace.xmu.edu.cn/handle/2288/87107]
专题	医学院－会议论文
推荐引用方式 GB/T 7714	Yin, Z.,Wang, X.,Li, N.,et al. Immunological advantage on small bowel graft induced by simultaneously transplanted liver in porcine auxiliary liver/small bowel transplantation. 2006-12-01.

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