Artificial neural network classification based on high-performance liquid chromatography of urinary and serum nucleosides for the clinical diagnosis of cancer

	Artificial neural network classification based on high-performance liquid chromatography of urinary and serum nucleosides for the clinical diagnosis of cancer
	Yang, J; Xu, GW; Kong, HW; Zheng, WF; Pang, T; Yang, Q
刊名	journal of chromatography b-analytical technologies in the biomedical and life sciences
	2002-11-15
卷号	780 期号:1 页码:27-33
关键词	artificial neural networks principal component analysis nucleosides
英文摘要	nucleosides in human urine and serum have frequently been studied as a possible biomedical marker for cancer, acquired immune deficiency syndrome (aids) and the whole-body turnover of rnas. fifteen normal and modified nucleosides were determined in 69 urine and 42 serum samples using high-performance liquid chromatography (hplc). artificial neural networks have been used as a powerful pattern recognition tool to distinguish cancer patients from healthy persons. the recognition rate for the training set reached 100%. in the validating set, 95.8 and 92.9% of people were correctly classified into cancer patients and healthy persons when urine and serum were used as the sample for measuring the nucleosides. the results show that the artificial neural network technique is better than principal component analysis for the classification of healthy persons and cancer patients based on nucleoside data. (c) 2002 elsevier science b.v. all rights reserved.
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	biochemical research methods ; chemistry, analytical
研究领域[WOS]	biochemistry & molecular biology ; chemistry
关键词[WOS]	pattern-recognition ; rp-hplc ; excretion ; electrophoresis ; pseudouridine ; phase
收录类别	SCI
原文出处	true
语种	英语
WOS记录号	WOS:000179110200004
公开日期	2010-11-30
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/84205]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A, Dalian 116012, Peoples R China
推荐引用方式 GB/T 7714	Yang, J,Xu, GW,Kong, HW,et al. Artificial neural network classification based on high-performance liquid chromatography of urinary and serum nucleosides for the clinical diagnosis of cancer[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2002,780(1):27-33.
APA	Yang, J,Xu, GW,Kong, HW,Zheng, WF,Pang, T,&Yang, Q.(2002).Artificial neural network classification based on high-performance liquid chromatography of urinary and serum nucleosides for the clinical diagnosis of cancer.journal of chromatography b-analytical technologies in the biomedical and life sciences,780(1),27-33.
MLA	Yang, J,et al."Artificial neural network classification based on high-performance liquid chromatography of urinary and serum nucleosides for the clinical diagnosis of cancer".journal of chromatography b-analytical technologies in the biomedical and life sciences 780.1(2002):27-33.