ApoE and A beta in Alzheimer's Disease: Accidental Encounters or Partners?

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	ApoE and A beta in Alzheimer's Disease: Accidental Encounters or Partners?
	Kanekiyo, Takahisa ; Xu, Huaxi ; Bu, Guojun ; Xu HX(许华曦) ; Bu GJ(卜国军)
刊名	http://dx.doi.org/10.1016/j.neuron.2014.01.045
	2014-02-19
关键词	DENSITY-LIPOPROTEIN RECEPTOR HUMAN APOLIPOPROTEIN-E CEREBRAL AMYLOID ANGIOPATHY HEPARAN-SULFATE PROTEOGLYCANS TRANSGENIC MOUSE MODEL CENTRAL-NERVOUS-SYSTEM BLOOD-BRAIN-BARRIER ISOFORM-SPECIFIC BINDING GENOME-WIDE ASSOCIATION AMINO-ACID-SEQUENCE
英文摘要	NIH [R01AG035355, R01AG027924, R01AG046205, P01AG030128, P01NS074969]; Alzheimer's Association IIRG; Cure Alzheimer's Fund; Mayo Clinic CRM Career Developmental Award; Alzheimer's Association NIRG; Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of Alzheimer's disease (AD). While transporting cholesterol is a primary function, apoE also regulates amyloid-beta (A beta) metabolism, aggregation, and deposition. Although earlier work suggests that different affinities of apoE isoforms to A beta might account for their effects on A beta clearance, recent studies indicate that apoE also competes with A beta for cellular uptake through apoE receptors. Thus, several factors probably determine the variable effects apoE has on A beta. In this Review, we examine biochemical, structural, and functional studies and propose testable models that address the complex mechanisms underlying apoE-A beta interaction and how apoE4 may increase AD risk and also serve as a target pathway for therapy.
语种	英语
出版者	CELL PRESS
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93665]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Kanekiyo, Takahisa,Xu, Huaxi,Bu, Guojun,et al. ApoE and A beta in Alzheimer's Disease: Accidental Encounters or Partners?[J]. http://dx.doi.org/10.1016/j.neuron.2014.01.045,2014.
APA	Kanekiyo, Takahisa,Xu, Huaxi,Bu, Guojun,许华曦,&卜国军.(2014).ApoE and A beta in Alzheimer's Disease: Accidental Encounters or Partners?.http://dx.doi.org/10.1016/j.neuron.2014.01.045.
MLA	Kanekiyo, Takahisa,et al."ApoE and A beta in Alzheimer's Disease: Accidental Encounters or Partners?".http://dx.doi.org/10.1016/j.neuron.2014.01.045 (2014).