Laboratorial characteristics of patients with diarrhoea suffering from egg white allergy

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	Laboratorial characteristics of patients with diarrhoea suffering from egg white allergy
	Liu, F. ; Lin, L. -R. ; Zhang, H. -L. ; Liu, G. -L. ; Tong, M. -L. ; Zeng, Y. -L. ; Huang, S. -J. ; Huang, C. -L. ; Liu, L. -L. ; Yang, T. -C. ; Liu F(刘风)
刊名	http://dx.doi.org/10.1016/j.aller.2013.04.001
	2014
关键词	OF-THE-ART HENS EGG FOOD ALLERGY CHILDREN SENSITIZATION MANAGEMENT DIAGNOSIS HORIZONS IGE
英文摘要	National Natural Science Foundation Major Research Plan [91029729]; National Natural Science Foundation [81171625, 81271335, 81201360, 81101324, 81141086, 81201305]; Technology Foundation's Major Project of Social Development in Fujian Province [2011Y4009]; Natural Science Foundation of Fujian Province [2012D039]; Youth research Foundation in Fujian Province [2008-1-55]; Background: Egg allergy is associated with diarrhoea( symptoms. However, the mechanism underlying allergic diarrhoea remains unclear. Objective: To determine whether egg white-specific IgE antibodies coexist with egg white-specific IgG antibodies in patients with egg allergy featuring diarrhoea( symptoms, and whether there is any relationship between these two antibody types. Methods: A total of 89 patients with egg allergy featuring diarrhoeal symptoms (average age, 23.2 years; range, 1-78 years), all of whom tested positive for egg white-specific IgG, were enrolled in this study. The concentration of total IgE, egg white-specific IgE and number of eosinophils in the serum were determined. Results: Among the 89 egg white allergic patients tested, 49 (55.1%) patients showed high reactivity to egg white-specific IgG, 48 (53.9%) patients had elevated serum total IgE levels, and 25 (28.1%) patients had elevated absolute eosinophil numbers. Out of the 89 egg white allergic patients, 25 showed elevated egg white-specific IgE antibody levels. Of the 25 patients who were positive for egg white-specific IgE antibody, 21 presented high sensitive reaction to egg white-specific IgG, three presented moderate sensitive reaction to egg white-specific IgG, and one presented mild sensitive reaction to egg white-specific IgG. A moderate correlation between egg white-specific IgG and egg white-specific IgE, egg white-specific IgG and absolute eosinophil number was found in the egg white allergic patients (r=0.438, P=0.000; r=0.322, P=0.002). Egg white-specific IgE levels varied in different age groups; the egg white-specific IgE concentration of younger patients (age <= 18 years, mean rank 54.29) was significantly higher than that of the adult patients (age > 18 years, mean rank 34.61) (Z= -3.629, P=0.000). Conclusion: Egg white-specific IgE antibody could coexist with egg white-specific IgG antibody in patients suffering from egg white allergy. Aberrant changes in the concentration of egg whitespecific IgE antibody were associated with the presence of egg white-specific IgG antibody. (C) 2013 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.
语种	英语
出版者	ELSEVIER DOYMA SL
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93617]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Liu, F.,Lin, L. -R.,Zhang, H. -L.,et al. Laboratorial characteristics of patients with diarrhoea suffering from egg white allergy[J]. http://dx.doi.org/10.1016/j.aller.2013.04.001,2014.
APA	Liu, F..,Lin, L. -R..,Zhang, H. -L..,Liu, G. -L..,Tong, M. -L..,...&刘风.(2014).Laboratorial characteristics of patients with diarrhoea suffering from egg white allergy.http://dx.doi.org/10.1016/j.aller.2013.04.001.
MLA	Liu, F.,et al."Laboratorial characteristics of patients with diarrhoea suffering from egg white allergy".http://dx.doi.org/10.1016/j.aller.2013.04.001 (2014).