Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapy

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	Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapy
	Huang, Peng ; Lin, Jing ; Wang, Shouju ; Zhou, Zhijun ; Li, Zhiming ; Wang, Zhe ; Zhang, Chunlei ; Yue, Xuyi ; Niu, Gang ; Yang, Min ; Cui, Daxiang ; Chen, Xiaoyuan ; Wang Z(王哲) ; Chen XY(陈小元)
刊名	http://dx.doi.org/10.1016/j.biomaterials.2013.02.063
	2013
关键词	SEMICONDUCTOR QUANTUM DOTS WALLED CARBON NANOTUBES PHOTOTHERMAL THERAPY MULTIFUNCTIONAL NANOPARTICLES NANORODS CANCER THERANOSTICS GENERATION DELIVERY SYSTEM
英文摘要	National Key Basic Research Program (973 Project) [2010CB933901, 2013CB733802]; National Science Foundation of China [81171399, 81272987, 51102258, 31170961, 81101101, 81230033, 81101077]; Jiangsu Province Foundation [BK2011166, BE2012622, BL2012031, RC2011095]; Zhejiang Province Foundation [LY12H11011]; Chinese Academy of Sciences professorship for Senior International Scientists [2011T2J06]; National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH); Multifunctional theranostics have recently been intensively explored to optimize the efficacy and safety of therapeutic regimens. In this work, a photo-theranostic agent based on chlorin e6 (Ce6) photosensitizer-conjugated silica-coated gold nanoclusters (AuNC5@SiO2 Ce6) is strategically designed and prepared for fluorescence imaging-guided photodynamic therapy (PDT). The AuNCs@SiO2 Ce6 shows the following features: i) high Ce6 photosensitizer loading; ii) no non-specific release of Ce6 during its circulation; iii) significantly enhanced cellular uptake efficiency of Ce6, offering a remarkably improved photodynamic therapeutic efficacy compared to free Ce6; iv) subcellular characterization of the nanoformula via both the fluorescence of Ce6 and plasmon luminescence of AuNCs; v) fluorescence imaging-guided photodynamic therapy (PDT). This photo-theranostics owns good stability, high water dispersibility and solubility, non-cytotoxicity, and good biocompatibility, thus facilitating its biomedical applications, particularly for multi-modal optical, CT and photoacoustic (PA) imaging-guided PDT or sonodynamic therapy. Published by Elsevier Ltd.
语种	英语
出版者	ELSEVIER SCI LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93544]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Huang, Peng,Lin, Jing,Wang, Shouju,et al. Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapy[J]. http://dx.doi.org/10.1016/j.biomaterials.2013.02.063,2013.
APA	Huang, Peng.,Lin, Jing.,Wang, Shouju.,Zhou, Zhijun.,Li, Zhiming.,...&陈小元.(2013).Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapy.http://dx.doi.org/10.1016/j.biomaterials.2013.02.063.
MLA	Huang, Peng,et al."Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapy".http://dx.doi.org/10.1016/j.biomaterials.2013.02.063 (2013).