Neuropsychiatric disorders secondary to neurosyphilis in elderly people: one theme not to be ignored

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	Neuropsychiatric disorders secondary to neurosyphilis in elderly people: one theme not to be ignored
	Zeng, Yan-Li ; Wang, Wen-Jie ; Zhang, Hui-Lin ; Chen, Fu-Yi ; Huang, Song-Jie ; Liu, Gui-Li ; Xi, Ya ; Guo, Xiao-Jing ; Zheng, Wei-Hong ; Yang, Tian-Ci ; Zheng WH(郑维红) ; Yang TC(杨天赐)
刊名	http://dx.doi.org/10.1017/S1041610213000896
	2013
关键词	GENERAL PARESIS CLINICAL PRESENTATION LABORATORY FINDINGS SYPHILIS PSYCHOSIS MANIFESTATIONS EPIDEMIOLOGY MANAGEMENT DIAGNOSIS SYMPTOM
英文摘要	National Natural Science Foundation's Major Research Planning [91029729]; National Natural Science Foundation [81171625, 81271335, 81101324, 81201360]; Technology Foundation's Major Project of Social Development in Fujian Province [2011Y4009]; Natural Science Foundation of Fujian Province [2012D039]; Background: Neurosyphilis (NS) may present with neuropsychiatric disorders characterized by cognitive impairment, personality disorders, and confusion, among others. Very few studies have focused on neuropsychiatric disorders secondary to NS in elderly people. Method: A retrospective chart review was performed to characterize the psychiatric findings, clinical signs and symptoms, laboratory findings, and brain magnetic resonance imaging results of ten elderly inpatients with NS. Results: In these ten patients, the most common presenting symptoms included a wide variety of psychiatric manifestations. The serum rapid plasma regain (RPR) and Treponema pallidum particle agglutination assay (TPPA) of the ten patients were positive, with positive CSF TPPA and RPR rates of 100% and 60%, respectively. In addition, 90% of the patients demonstrated abnormal imaging, including cerebral atrophy, infarct ischemic stroke, and hydrocephalus. Conclusions: Our findings support the importance of serological tests for syphilis as a routine component of the evaluation of patients with clinically evident neurological or psychiatric symptoms. If the serology is positive, all of the patients should be examined with a lumbar puncture. Moreover, psychiatric illnesses secondary to NS in the elderly also deserve medical attention.
语种	英语
出版者	CAMBRIDGE UNIV PRESS
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93506]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Zeng, Yan-Li,Wang, Wen-Jie,Zhang, Hui-Lin,et al. Neuropsychiatric disorders secondary to neurosyphilis in elderly people: one theme not to be ignored[J]. http://dx.doi.org/10.1017/S1041610213000896,2013.
APA	Zeng, Yan-Li.,Wang, Wen-Jie.,Zhang, Hui-Lin.,Chen, Fu-Yi.,Huang, Song-Jie.,...&杨天赐.(2013).Neuropsychiatric disorders secondary to neurosyphilis in elderly people: one theme not to be ignored.http://dx.doi.org/10.1017/S1041610213000896.
MLA	Zeng, Yan-Li,et al."Neuropsychiatric disorders secondary to neurosyphilis in elderly people: one theme not to be ignored".http://dx.doi.org/10.1017/S1041610213000896 (2013).