Resveratrol Protects Mouse Oocytes from Methylglyoxal-Induced Oxidative Damage

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	Resveratrol Protects Mouse Oocytes from Methylglyoxal-Induced Oxidative Damage
	Liu, Yu ; He, Xiao-Qin ; Huang, Xin ; Ding, Lu ; Xu, Lin ; Shen, Yu-Ting ; Zhang, Fei ; Zhu, Mao-Bi ; Xu, Bai-Hui ; Qi, Zhong-Quan ; Wang, Hai-Long ; He XQ(何小琴) ; Zhang F(张菲)
刊名	http://dx.doi.org/10.1371/journal.pone.0077960
	2013
关键词	DNA-DAMAGE IN-VITRO PARTHENOGENETIC ACTIVATION DIABETIC COMPLICATIONS CHROMOSOME SEGREGATION MAMMALIAN OOCYTES INDUCED APOPTOSIS CARBONYL STRESS LDL OXIDATION FERTILIZATION
英文摘要	National Natural Science Foundation of China [31201695]; Major State Scientific Research Program of China [2012CBA01303]; Methylglyoxal, a reactive dicarbonyl compound, is mainly formed from glycolysis. Methylglyoxal can lead to the dysfunction of mitochondria, the depletion of cellular anti-oxidation enzymes and the formation of advanced glycation ends. Previous studies showed that the accumulation of methylglyoxal and advanced glycation ends can impair the oocyte maturation and reduce the oocyte quality in aged and diabetic females. In this study, we showed that resveratrol, a kind of phytoalexin found in the skin of grapes, red wine and other botanical extracts, can alleviate the adverse effects caused by methylglyoxal, such as inhibition of oocyte maturation and disruption of spindle assembly. Besides, methylglyoxal-treated oocytes displayed more DNA double strands breaks and this can also be decreased by treatment of resveratrol. Further investigation of these processes revealed that methylglyoxal may affect the oocyte quality by resulting in excessive reactive oxygen species production, aberrant mitochondrial distribution and high level lipid peroxidation, and resveratrol can block these cytotoxic changes. Collectively, our results showed that resveratrol can protect the oocytes from methylglyoxal-induced cytotoxicity and this was mainly through the correction of the abnormity of cellular reactive oxygen species metabolism.
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93467]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Liu, Yu,He, Xiao-Qin,Huang, Xin,et al. Resveratrol Protects Mouse Oocytes from Methylglyoxal-Induced Oxidative Damage[J]. http://dx.doi.org/10.1371/journal.pone.0077960,2013.
APA	Liu, Yu.,He, Xiao-Qin.,Huang, Xin.,Ding, Lu.,Xu, Lin.,...&张菲.(2013).Resveratrol Protects Mouse Oocytes from Methylglyoxal-Induced Oxidative Damage.http://dx.doi.org/10.1371/journal.pone.0077960.
MLA	Liu, Yu,et al."Resveratrol Protects Mouse Oocytes from Methylglyoxal-Induced Oxidative Damage".http://dx.doi.org/10.1371/journal.pone.0077960 (2013).