Novel function of N,N-bis(2-chloroethyl)docos-13-enamide for reversal of multidrug resistance in tongue cancer

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	Novel function of N,N-bis(2-chloroethyl)docos-13-enamide for reversal of multidrug resistance in tongue cancer
	Qin, Qing ; Ma, Peng-Fei ; Kuang, Xiao-Cong ; Gao, Ming-Xing ; Mo, De-Huan ; Xia, Shuang ; Jin, Ning ; Xia, Jun-Jie ; Qi, Zhong-Quan ; Lin, Cui-Wu ; Qi ZQ(齐忠权)
刊名	http://dx.doi.org/10.1016/j.ejphar.2013.09.033
	2013
关键词	GLUTATHIONE S-TRANSFERASES ANTICANCER DRUG-RESISTANCE SIGNAL-TRANSDUCTION CELLS MECHANISMS KINASES ENZYMES
英文摘要	National Natural Science Foundation of China [30560186]; Department of International Cooperation and Exchanges, Ministry of Education of PR China [20031593]; Guangxi Sciences Foundation [0728128, 0991147, 2013-GXNSFAA019160]; Innovation Project of Guangxi Graduate Education; Multidrug resistance (MDR) is a key element in the failure of chemotherapies, and development of agents to overcome MDR is crucial to improving cancer treatments. The overexpression of glutathione-S-transferases (GSTs) is one of the major mechanisms of MDR. Because some agents used in traditional Chinese medicine have strong antitumor effects coupled with low toxicity; we investigated the ability of N,N-bis(2-chloroethyl)docos-13-enamide (compound J), the synthesized analog of a highly unsaturated fatty acid from Isatis tinctoria L. to reverse the MDR induced by adriamycin (ADM) in TCA8113/ADM cells. We found that compound J significantly increased the cytotoxicity of ADM in TCA8113/ADM cells, with a reversal fold of 2.461. Analysis of the mechanisms through which compound J reversed MDR indicated that compound J significantly decreased the activity of GSTs and enhanced the depletion of GSH in TCA8113/ADM cells, but did not affect the P-glycoprotein (P-gp) efflux. Taken together, our data suggested that compound J was an excellent candidate for reversing MDR in cancer therapy. (C) 2013 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93420]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Qin, Qing,Ma, Peng-Fei,Kuang, Xiao-Cong,et al. Novel function of N,N-bis(2-chloroethyl)docos-13-enamide for reversal of multidrug resistance in tongue cancer[J]. http://dx.doi.org/10.1016/j.ejphar.2013.09.033,2013.
APA	Qin, Qing.,Ma, Peng-Fei.,Kuang, Xiao-Cong.,Gao, Ming-Xing.,Mo, De-Huan.,...&齐忠权.(2013).Novel function of N,N-bis(2-chloroethyl)docos-13-enamide for reversal of multidrug resistance in tongue cancer.http://dx.doi.org/10.1016/j.ejphar.2013.09.033.
MLA	Qin, Qing,et al."Novel function of N,N-bis(2-chloroethyl)docos-13-enamide for reversal of multidrug resistance in tongue cancer".http://dx.doi.org/10.1016/j.ejphar.2013.09.033 (2013).