Metabolomic Profilings of Urine and Serum from High Fat-Fed Rats via H-1 NMR Spectroscopy and Pattern Recognition

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	Metabolomic Profilings of Urine and Serum from High Fat-Fed Rats via H-1 NMR Spectroscopy and Pattern Recognition
	Xu, Jingjing ; Liu, Changqin ; Cai, Shuhui ; Dong, Jiyang ; Li, Xuejun ; Feng, Jianghua ; Chen, Zhong ; Xu JJ(徐静静) ; Li XJ(李学军) ; Cai SH(蔡淑惠) ; Dong JY(董继扬) ; Feng JH(冯江华) ; Chen Z(陈忠)
刊名	http://dx.doi.org/10.1007/s12010-012-0072-3
	2013
关键词	INSULIN-RESISTANCE OBESE RATS METABONOMIC ANALYSIS NMR-SPECTROSCOPY DIET TAURINE METABOTYPE EXPRESSION SYSTEMS PLASMA
英文摘要	NNSF of China [11074209, 81201143, 81073113]; Fundamental Research Funds for the Central Universities [2011121046]; Excellent Youth Foundation of Fujian Province [2009D016]; Xiamen Research Platform on Systems Biology of Metabolic Diseases; H-1 NMR spectroscopy in combination with multivariate statistical analysis was applied to explore the metabolic variability in urine and serum of high fat-fed rats relative to normal chow-fed ones. Metabolites contributing to intergroup discrimination identified by partial least squares discriminant analysis include 3-hydroxybutyrate, glutamate, glutamine, citrate, choline, hippurate, alanine, lactate, creatinine, taurine, acetate, etc. The aging effect along with long-term feeding was delineated with metabolic trajectory in principal component analysis score plot and age-related differences on metabolic profiling under different dietary intervention were recognised. The identified metabolites responsible for obesity were all imported into a web tool for network-based interpretation of compound lists to interpret their functional context, molecular mechanisms and disturbed signalling pathway globally and systematically. The results are useful for interpreting the pathology of obesity and further probing into the relationship between dietary-induced obesity and type 2 diabetes mellitus.
语种	英语
出版者	HUMANA PRESS INC
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93397]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Xu, Jingjing,Liu, Changqin,Cai, Shuhui,et al. Metabolomic Profilings of Urine and Serum from High Fat-Fed Rats via H-1 NMR Spectroscopy and Pattern Recognition[J]. http://dx.doi.org/10.1007/s12010-012-0072-3,2013.
APA	Xu, Jingjing.,Liu, Changqin.,Cai, Shuhui.,Dong, Jiyang.,Li, Xuejun.,...&陈忠.(2013).Metabolomic Profilings of Urine and Serum from High Fat-Fed Rats via H-1 NMR Spectroscopy and Pattern Recognition.http://dx.doi.org/10.1007/s12010-012-0072-3.
MLA	Xu, Jingjing,et al."Metabolomic Profilings of Urine and Serum from High Fat-Fed Rats via H-1 NMR Spectroscopy and Pattern Recognition".http://dx.doi.org/10.1007/s12010-012-0072-3 (2013).