Influence of Refractive Error on Optic Disc Topographic Parameters: The Singapore Malay Eye Study

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	Influence of Refractive Error on Optic Disc Topographic Parameters: The Singapore Malay Eye Study
	Wu, Ren-Yi ; Wong, Tien-Yin ; Zheng, Ying-Feng ; Cheung, Carol Yim-Lui ; Perera, Shamira A. ; Saw, Seang Mei ; Aung, Tin ; Wu RY(吴仁毅)
刊名	http://dx.doi.org/10.1016/j.ajo.2011.01.018
	2011-07
关键词	NERVE-FIBER LAYER SCANNING LASER OPHTHALMOSCOPY HEIDELBERG RETINA TOMOGRAPHY COHERENCE TOMOGRAPHY DETECTING GLAUCOMA MYOPIC EYES POPULATION PREVALENCE THICKNESS HEAD
英文摘要	NATIONAL Medical Research Council, Singapore [0796/2003, 0863/2004, CSI/0002/2005]; Biomedical Research Council, Singapore [501/1/25-5]; Singapore Tissue Network; Ministry of Health, Singapore, Republic of Singapore; PURPOSE: To examine the relationship between refractive error and optic disc topographic parameters and retinal nerve fiber layer (RNFL) thickness. DESIGN: Population-based cross-sectional study. METHODS: All 3280 (78.7% response rate) persons of Asian Malay ethnicity 40 to 80 years of age underwent a standardized interview, ocular examinations, and optic disc imaging with the Heidelberg Retina Tomography II (HRT; Heidelberg Engineering). Associations between spherical equivalent (SE) and HRT parameters were evaluated by partial correlation analysis. RESULTS: There were 2457 (74.9%) right eyes with good-quality HRT images for analyses. When compared with emmetropic 'eyes, highly myopic eyes (SE < -6.0 diopters) had greater disc area, rim area, rim volume, whereas hyperopic eyes (SE > 0.5 diopters) had significantly smaller disc area, rim area, and cross-sectional RNFL area (all P < .005). In partial correlation after adjustment for age, sex, body mass index, intraocular pressure, and optic disc area, increase of SE (toward hyperopia) was related significantly with greater cup area (partial correlation coefficient, r = 0.058; P = .004) and cup-to-disc area ratio (r = 0.058; P = .004) and with smaller optic disc area (r = 0.058; P = .004), rim area (r = 0.058; P = .004), and rim volume (r = 0.091; P < .001). CONCLUSIONS: This population-based study shows that refractive error is significantly (but weakly) associated with HRT parameters of disc area, cup area, rim area, cup-to-disc area ratio, and rim volume. The clinical significance of these associations need to be determined in further studies. (Am J Ophthalmol 2011;152:81-86. (C) 2011 by Elsevier Inc. All rights reserved.)
语种	英语
出版者	AM J OPHTHALMOL
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93287]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Wu, Ren-Yi,Wong, Tien-Yin,Zheng, Ying-Feng,et al. Influence of Refractive Error on Optic Disc Topographic Parameters: The Singapore Malay Eye Study[J]. http://dx.doi.org/10.1016/j.ajo.2011.01.018,2011.
APA	Wu, Ren-Yi.,Wong, Tien-Yin.,Zheng, Ying-Feng.,Cheung, Carol Yim-Lui.,Perera, Shamira A..,...&吴仁毅.(2011).Influence of Refractive Error on Optic Disc Topographic Parameters: The Singapore Malay Eye Study.http://dx.doi.org/10.1016/j.ajo.2011.01.018.
MLA	Wu, Ren-Yi,et al."Influence of Refractive Error on Optic Disc Topographic Parameters: The Singapore Malay Eye Study".http://dx.doi.org/10.1016/j.ajo.2011.01.018 (2011).